• Publications
  • Influence
Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking: A PET/[11C]Raclopride Study in Healthy Men
Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using:Expand
  • 377
  • 18
  • PDF
Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men.
CONTEXT In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced psychomotor response and increased dopamine release. This phenomenon, known as sensitization, may conferExpand
  • 294
  • 17
  • PDF
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
Risperidone is a relatively new antipsychotic drug that has been reported to improve both the positive and the negative symptoms of schizophrenia and produces relatively few extrapyramidal sideExpand
  • 214
  • 15
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
The 3,4-methylenedioxy analogues of amphetamine [MDMA ("Ecstasy", "Adam"), MDA ("Love") and MDE ("Eve")] are recreational drugs that produce feelings of euphoria and energy and a desire to socialize,Expand
  • 183
  • 14
A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates.
A continuous, peroxidase-linked spectrophotometric assay is described which is suitable for measuring monoamine and diamine oxidase and semicarbazide-sensitive amine oxidase activities in tissueExpand
  • 195
  • 12
Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement
HeadingAbstractRationale. Responding for conditioned reinforcement is increased by the dopamine releasing agent amphetamine, but reduced by drugs that enhance serotonin (5-HT) function. TheExpand
  • 80
  • 12
  • PDF
Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
Abstract The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative ofExpand
  • 159
  • 10
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.
The metabolism of the antidepressant drug trazodone to its active metabolite, m-chlorophenylpiperazine (mCPP), was studied in vitro using human liver microsomal preparations and cDNA-expressed humanExpand
  • 99
  • 10
  • PDF
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology.
Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and postmortem by neuriticExpand
  • 203
  • 8
  • PDF
Interactions between the cytochrome P450 system and the second-generation antipsychotics.
Awareness of the metabolism of second-generation antipsychotics by the cytochrome P450 (CYP) system can inform the clinician about how to avoid and manage drug-drug interactions involving theseExpand
  • 140
  • 8
  • PDF