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Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men.
A high novelty-seeking personality trait and self-rating assessments indicating impulsivity predicted proneness to sensitization, and Sensitization to stimulants can be achieved in healthy men in the laboratory.
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
The formation of 9-Hydroxyrisperidone is highly correlated with testosterone 6β-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of ris peridone in rat.
Impaired neurosteroid synthesis in multiple sclerosis.
These multi-platform studies point to impaired neurosteroidogenesis in both multiple sclerosis and experimental autoimmune encephalomyelitis, and indicate that allopregnanolone and perhaps other neurosteroids-like compounds might represent potential biomarkers or therapies for multiple sclerosis.
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement
Results show that 5-HT2A and5-HT1B/1D receptors play a facilitatory role in mediating the stimulant effect of MDMA, whereas 5- HT2C receptors are inhibitory, which contributes to the deficit in operant responding.
MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase‐6 regulates astrocyte survival
Data point to previously unrecognized alterations in miRNA profile in the brain during HIV infection, which contribute to cell death through dysregulation of cell death machinery, as well as new aspects of HIV neurodegeneration.
A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates.
This inexpensive assay which employs reagents with low toxicity can thus be used to determine the degree of inhibition of MAO elicited by potential antidepressant and anti-parkinsonian agents.
Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
The results of the present study indicated that, at low doses, venlafaxine inhibited serotonin reuptake, while at higher doses it inhibited both serotonin and noradrenaline reuptakes.
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.
The present results indicate that trazodone is a substrate for CYP3A4, that CYP 3A4 is a major isoform involved in the production of mCPP from traZodone, and that there is the possibility of drug-drug interactions with trazidone and other substrates, inducers and/or inhibitors of CYP2A4.