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- Publications
- Influence
Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking: A PET/[11C]Raclopride Study in Healthy Men
- M. Leyton, I. Boileau, C. Benkelfat, M. Diksic, G. Baker, A. Dagher
- Psychology, Medicine
- Neuropsychopharmacology
- 1 December 2002
Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.). PET data were analyzed using:… Expand
Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men.
- I. Boileau, A. Dagher, +4 authors C. Benkelfat
- Psychology, Medicine
- Archives of general psychiatry
- 1 December 2006
CONTEXT
In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced psychomotor response and increased dopamine release. This phenomenon, known as sensitization, may confer… Expand
Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
- J. Fang, M. Bourin, G. Baker
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 25 January 1999
Risperidone is a relatively new antipsychotic drug that has been reported to improve both the positive and the negative symptoms of schizophrenia and produces relatively few extrapyramidal side… Expand
3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans
- K. Hegadoren, G. Baker, M. Bourin
- Psychology, Medicine
- Neuroscience & Biobehavioral Reviews
- 1 March 1999
The 3,4-methylenedioxy analogues of amphetamine [MDMA ("Ecstasy", "Adam"), MDA ("Love") and MDE ("Eve")] are recreational drugs that produce feelings of euphoria and energy and a desire to socialize,… Expand
A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates.
- A. Holt, D. Sharman, G. Baker, M. Palcic
- Chemistry, Medicine
- Analytical biochemistry
- 15 January 1997
A continuous, peroxidase-linked spectrophotometric assay is described which is suitable for measuring monoamine and diamine oxidase and semicarbazide-sensitive amine oxidase activities in tissue… Expand
Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement
- P. Fletcher, K. M. Korth, S. Robinson, G. Baker
- Psychology, Medicine
- Psychopharmacology
- 14 May 2002
HeadingAbstractRationale. Responding for conditioned reinforcement is increased by the dopamine releasing agent amphetamine, but reduced by drugs that enhance serotonin (5-HT) function. The… Expand
Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
- J. P. Redrobe, M. Bourin, M. C. Colombel, G. Baker
- Medicine, Psychology
- Psychopharmacology
- 1 July 1998
Abstract The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of… Expand
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.
- S. Rotzinger, J. Fang, G. Baker
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 June 1998
The metabolism of the antidepressant drug trazodone to its active metabolite, m-chlorophenylpiperazine (mCPP), was studied in vitro using human liver microsomal preparations and cDNA-expressed human… Expand
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology.
- Timothy J Revett, G. Baker, Jack Jhamandas, S. Kar
- Biology, Medicine
- Journal of psychiatry & neuroscience : JPN
- 2013
Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and postmortem by neuritic… Expand
Interactions between the cytochrome P450 system and the second-generation antipsychotics.
- Trevor I. Prior, G. Baker
- Medicine
- Journal of psychiatry & neuroscience : JPN
- 1 March 2003
Awareness of the metabolism of second-generation antipsychotics by the cytochrome P450 (CYP) system can inform the clinician about how to avoid and manage drug-drug interactions involving these… Expand