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Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample.
Psychiatric disorders are common and frequently multiple in children with autism spectrum disorders and should be routinely evaluated in the clinical assessment of this group. Expand
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
Prevalence of autism and related ASDs is substantially greater than previously recognised and services in health, education, and social care will need to recognise the needs of children with some form of ASD, who constitute 1% of the child population. Expand
Functional impact of global rare copy number variation in autism spectrum disorders
The genome-wide characteristics of rare (<1% frequency) copy number variation in ASD are analysed using dense genotyping arrays to reveal many new genetic and functional targets in ASD that may lead to final connected pathways. Expand
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
Linkage and copy number variation analyses implicate chromosome 11p12–p13 and neurexins, respectively, among other candidate loci, highlighting glutamate-related genes as promising candidates for contributing to ASDs. Expand
Infants with autism: an investigation of empathy, pretend play, joint attention, and imitation.
Compared with developmentally delayed and normally developing children, 20-month-old children with autism were specifically impaired on some aspects of empathy, joint attention, and imitation. Expand
A screening instrument for autism at 18 months of age: a 6-year follow-up study.
The CHAT can be used to identify cases of autism and related pervasive developmental disorders at 18 months of age and has a sensitivity of 38% and a specificity of 98% for identifying CA. Expand
Psychological markers in the detection of autism in infancy in a large population.
Consistent failure of the three key items from the CHAT at 18 months of age carries an 83.3% risk of autism; and this pattern of risk indicator is specific to autism when compared to other forms of developmental delay. Expand
Impairment in movement skills of children with autistic spectrum disorders
This study aims to explore the degree of impairment in movement skills in children with autistic spectrum disorders (ASD) and a wide IQ range. Expand
The impact of nonverbal ability on prevalence and clinical presentation of language disorder: evidence from a population study
At school entry, approximately two children in every class of 30 pupils will experience language disorder severe enough to hinder academic progress, and access to specialist clinical services should not depend on NVIQ. Expand
Autism spectrum disorders at 20 and 42 months of age: stability of clinical and ADI-R diagnosis.
The association between, and stability of, clinical diagnosis and diagnosis derived from the Autism Diagnostic Interview-Revised (ADI-R; Lord, Rutter, & Le Couteur, 1994) was examined in a sample ofExpand