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Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans- activation
TLDR
Regulation of HIV-1 gene expression by Rev involves the targeting of RRE-containing RNA to components of the cellular translation initiation complex and is able to block Rev function in mammalian cells by antisense inhibition of eIF-5A gene expression. Expand
Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages.
TLDR
Observations suggest that immediate response of NODs to endotoxins could result from NF-kappaB activation via TLR signaling, whereas the second rise in NOD mRNAs might have resulted from TNF-alpha production possibly through NF- kappaB, TLR, and/or NOD signalings. Expand
Up-Regulation of NOD1 and NOD2 through TLR4 and TNF-α in LPS-treated Murine Macrophages
TLDR
Observations suggest that immediate response of NODs to endotoxins could result from NF-kappaB activation via TLR signaling, whereas the second rise in NOD mRNAs might have resulted from TNF-alpha production possibly through NF- kappaB, TLR, and/or NOD signalings. Expand
Interleukin-16 (IL-16) inhibits human immunodeficiency virus replication in cells from infected subjects, and serum IL-16 levels drop with disease progression.
TLDR
Analysis of serum samples from HIV-1-infected subjects over a period of 8 years showed maintained or even increased IL-16 levels during the whole asymptomatic phase and a significant drop on progression to disease. Expand
Interleukin-16 Inhibits Human Immunodeficiency Virus Type 1 Entry and Replication in Macrophages and in Dendritic Cells
TLDR
A critical role is established for rIL-16 in protecting APCs against HIV-1 infection and further support is lent to its potential use in the treatment of HIV disease. Expand
Elevated IgG Antibody Levels to the Mycobacterial 65‐kDa Heat Shock Protein Are Characteristic of Patients with Rheumatoid Arthritis
TLDR
Elevated IgG antibody levels to the mycobacterial hsp65 shows some disease specificity, and further studies with the human homologue and at the T‐cell level are required. Expand
Selective induction of CD11a,b,c/CD18 and CD54 expression at the cell surface of human leukocytes by muramyl peptides.
TLDR
The results indicate that MDPs seem to act preferentially on monocytes and PMNs in increasing the level of molecules involved in cellular adhesion process, either in provoking the expression of preformed molecules or in inducing their synthesis. Expand
Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine.
TLDR
It is shown that DNA prime/protein boost vaccine combinations increase the humoral and cellular immune responses against HIV-1 Nef and that the co-injection of DNA encoding Interleukin-18 (IL-18) modulates the specific immune response towards a Th1 type. Expand
SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus.
TLDR
Interestingly, the incidence of antibodies to SS-56 was associated with visceral complications in SLE, and roughly half of the 17 SS or SLE patients with no detectable antibodies to SSA and SSB antigens presented measurable antibodies against recombinant SS- 56. Expand
A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.
TLDR
The cloning and identification of a Murabutide-downregulated gene, named RH116, bearing classical motifs that are characteristic of the DExH family of RNA helicases are reported, implicate RH116 in the regulation of HIV-1 replication and point to an apoptosis-independent role for this novel helicase in inducing cell growth arrest. Expand
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