Indapamide. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.
It appears that indapamide shares the potential with other diuretic agents to induce electrolyte and other metabolic abnormalities, although it may do so with less frequency or severity, and appears to offer a suitable alternative to more established drugs as a 'first-line' treatment in patients with mild to moderate hypertension.
Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.
The overall incidence of side effects seen with guanabenz was at least as high as with methyldopa or clonidine, and side effects such as drowsiness or dry mouth have been bothersome enough to lead to discontinuation of guan abenz therapy in some patients.
Trimethoprim: A Review of its Antibacterial Activity, Pharmacokinetics and Therapeutic Use in Urinary Tract Infections
There is no conclusive evidence that there will be a more rapid increase following the introduction of trimethoprim for use alone in the treatment of urinary tract infections, but it is clearly important, therefore, that the levels and mechanisms of trimETHoprim-resistance among urinary pathogens be carefully monitored.
Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use.
It appears that flunarizine will offer a useful alternative in some therapeutic areas that can be difficult to manage with previously available therapy, however, a definitive statement on its relative place in therapy of such conditions must await a few well-controlled comparative studies.
Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.
Alleviation of the dose-limiting peripheral side effects of the anti-Parkinsonian drugs bromocriptine and levodopa, enables a higher optimum dose, with consequent improvement in Parkinsonian symptoms.
Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus.
Initial trials have suggested that gliclazide therapy may reverse or at least slow down the progression of diabetic retinopathy, however, a few additional well-designed long term controlled studies are needed to confirm these findings, and to clarify whether any beneficial effect on diabetic Retinopathy is unique to glic lazide or also occurs with other oral hypoglycaemic drugs.
Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy
Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine.
Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.
In immunocompromised patients, both intravenous and topical acyClovir shortened the clinical course of herpes simplex virus infections occurring mainly on the lips, oral mucosa and face, and prophylaxis with either oral or intravenous acyclovir suppressed the appearance of recurrent lesions from latent virus for the period of drug administration, but acy Clovir did not eradicate latent herpesviruses.
Ketoconazole: A Review of its Therapeutic Efficacy in Superficial and Systemic Fungal Infections
Ketoconazole was effective in treating dermatophytic infections in guinea-pigs, and a wide variety of superficial and systemic candidal infections, and combined treatment of cryptococcosis with ketoconazoles plus amphotericin B tended to be more effective than either drug alone in reducing mortality.
Ursodeoxycholic acid: a review of its pharmacological properties and therapeutic efficacy.
While surgery is clearly the preferred treatment in many patients with symptomatic gallstones, in a carefully selected subgroup of such patients gallstone dissolution therapy with ursodeoxycholic acid offers an important and worthwhile alternative.