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Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial
TLDR
Pentavalent rotvirus vaccine is effective against severe rotavirus gastroenteritis in the first 2 years of life in African countries with high mortality in infants younger than 5 years and supports WHO's recommendation for adoption of rotav virus vaccine into national expanded programmes on immunisation in Africa.
Impact of permethrin impregnated bednets on child mortality in Kassena‐Nankana district, Ghana: a randomized controlled trial
TLDR
The ready acceptance of bednets, the high level of compliance in their use and the subsequent impact on all‐cause mortality in this study has important implications for programmes to control malaria in sub‐Saharan Africa.
Burden and epidemiology of rotavirus diarrhea in selected African countries: preliminary results from the African Rotavirus Surveillance Network.
TLDR
Preliminary results indicate that rotavirus is a major cause of severe diarrheal disease in African children.
Changing Patterns of Rotavirus Genotypes in Ghana: Emergence of Human Rotavirus G9 as a Major Cause of Diarrhea in Children
TLDR
Genotyping of human rotaviruses was performed on 312 rotavirus-positive samples collected from 2,205 young children with diarrhea in the Upper East District of Ghana, a rural community, and found the predominant G9 genotype was G9P, which constituted 79.5% of all G9 strains detected.
Prevalence of unusual human rotavirus strains in Ghanaian children
TLDR
The presence of these unusual strains, especially the high incidence of G2 rotavirus strains in Ghana, reinforces the need to put in place a surveillance system for the detection of new and exotic rotvirus strains, that will provide information on the spread of these strains in West Africa as well as useful data for the formulation of the next generation of rotav virus vaccines.
Genomic characterization of human rotavirus G8 strains from the African rotavirus network: Relationship to animal rotaviruses
TLDR
This study suggests that the ARN G8 strains might have arisen through VP7 or VP4 gene reassortment events since most of the other gene segments resemble those of common human rotaviruses.
New oligonucleotide primers for P-typing of rotavirus strains: Strategies for typing previously untypeable strains.
TLDR
This study highlights the importance of a constant reconsideration of primer sequences employed for the molecular typing of rotaviruses, and design and evaluate a new VP4 consensus oligonucleotide primer pair that provides increased sensitivity and allows typing of strains that were untypeable using available methods.
Significant Correlation Between the Infant Gut Microbiome and Rotavirus Vaccine Response in Rural Ghana
TLDR
The intestinal microbiome composition correlates significantly with RVV immunogenicity and may contribute to the diminished RVV Immunogenicity observed in developing countries.
Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years
TLDR
It is suggested that prioritizing vaccine introduction and interventions to reduce diarrhea-associated morbidity and mortality is necessary in the continued global reduction of rotavirus infection.
Diversity of rotavirus strains circulating in west Africa from 1996 to 2000.
TLDR
Rotavirus G9 strains were detected with increasing frequency across the region, but rotav virus G4 strains were seen only in Cameroon, and strains with P[4] specificities were relatively rare, except in Ghana and Cameroon.
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