G. Arendt

Publications167
h-index32
Citations6,506
Highly Influential Citations451
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Updated research nosology for HIV-associated neurocognitive disorders
TLDR
This report reviews the collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neuroc cognitive impairment to categorize individuals with subclinical impairment.
View on Wolters Kluwer
Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
View on Elsevier
Immune surveillance in multiple sclerosis patients treated with natalizumab
TLDR
Whether natalizumab, an antibody against very late activating antigen (VLA)‐4, interferes with central nervous system immune surveillance as assessed by leukocyte cell numbers and cellular phenotypes in cerebrospinal fluid (CSF) and peripheral blood is tested.
View on Wiley
Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis.
TLDR
Natalizumab therapy decreased the CSF CD4(+)/CD8(+) ratio of patients with MS to levels similar to those of human immunodeficiency virus-infected patients, which may have implications for the observation that some natalizUMab-treated Patients with MS developed progressive multifocal leukoencephalopathy.
View on PubMed
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment
TLDR
An overview of the current concepts in the field of HAND is given and suggestions for the diagnostic and therapeutic management are provided.
View on Springer
HIV dementia: the role of the basal ganglia and dopaminergic systems
TLDR
The evidence for involvement of basal ganglia and, in particular, the dopaminergic systems, in HIV dementia is described and novel therapeutic strategies that may be beneficial in the treatment of this disorder are suggested.
View on SAGE
A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies
TLDR
GBP was more effective than placebo in reducing pain and sleep interference in patients with HIV-SN, and was generally well tolerated.
View on Springer
Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain
TLDR
Treatment with the capsaicin 8% cutaneous patch was generally safe and well tolerated and a modified quantitative sensory testing (QST) should be developed for clinical practice in order to better understand the correlation of sensory profiles and response to Capsaicin treatment.
View on Taylor & Francis
Increased dopaminergic neurotransmission in therapy-naïve asymptomatic HIV patients is not associated with adaptive changes at the dopaminergic synapses
TLDR
These findings show activation of central DA systems without development of adaptive responses at DA synapses in asymptomatic HIV infection, providing a clue to the synergism between DA medication or drugs of abuse and HIV infection to exacerbate and accelerate HIV neuropsychiatric disease, a central issue in the neurobiology of HIV.
View on Springer
Early microstructural white matter changes in patients with HIV: A diffusion tensor imaging study
TLDR
Patients with HIV-MRN have evidence of FA-alterations in similar regions that are lesioned in HIV-MRL patients, suggesting common neuropathological processes, and these results suggest a biological rather than a reactive origin of depression in AIDS-patients.
View on Springer
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