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The proteasome inhibitor PS-341 in cancer therapy.
TLDR
The anticancer activity of the boronic acid dipeptide proteasome inhibitor PS-341 was examined in vitro and in vivo, and it seemed to produce primarily additive tumor growth delays against the s.c. tumor. Expand
Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
TLDR
PXD101 was found to inhibit in vitro cancer cell growth at sub- to low micromolar IC50 potency, exhibited synergistic activity when used in combination with relevant chemotherapeutics, and effectively inhibited the growth of multidrug-resistant cells. Expand
Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells.
TLDR
The most effective, N,N'-bis(2-ethyl-1,3-dioxolane)kryptocyanine (EDKC), caused marked, light-dependent killing of human bladder, squamous, and colon carcinoma cell lines after 30-min incubations at 1-0.01 microM but was minimally toxic to human keratinocytes and to normal monkey kidney epithelial cells (CV-1). Expand
Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer
TLDR
Belinostat inhibited the migration of prostate tumor cells and increased the production of tissue inhibitor of metalloproteinase‐1 by these cells, the latter effect being replicated by siRNA knockdown of HDAC3. Expand
The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
TLDR
The data demonstrate that belinostat inhibits bladder cancer and supports the clinical evaluation of bel inostat for the treatment of patients with superficial bladder cancer. Expand
Enhancement of alkylating agent activity by SR-4233 in the FSaIIC murine fibrosarcoma.
TLDR
The results suggest that SR-4233 may have the potential to improve the clinical efficacy of commonly used antitumor alkylating agents. Expand
Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma.
TLDR
The efficacy of squalamine alone and along with cytotoxic therapies against a model of primary and systemic disease was determined and it was found thatSqualamine administration alone substantially decreased the number of lung metastases found in animals bearing the Lewis lung carcinoma and further decreased theNumber of Lung metastases when administered along with the chemotherapeutic agents. Expand
Reversal of in vivo drug resistance by the transforming growth factor‐β inhibitor decorin
TLDR
Animals bearing the resistant tumors have higher plasma levels of TGF‐β than animals bearing the parent tumors; however, upon treatment with cytotoxic therapies there is a greater rise in plasma TGF-β levels in animals Bearing the parent tumor than in animalsbearing the resistant tumor. Expand
Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents
TLDR
TNP‐470, especially in combination with minocycline, formed a highly effective modulator combination for treatment of the Lewis lung carcinoma with cytotoxic cancer therapies against primary and metastatic disease. Expand
Irradiation of pigmented melanoma cells with high intensity pulsed radiation generates acoustic waves and kills cells
TLDR
Data indicate that pigmented cell killing is due to absorption of radiation by melanin and that the pulsewidth and intensity of radiation play important roles in cell killing, and that thermal confinement of high intensity, short‐pulse visible radiation generates acoustic waves by thermal expansion, leading to mechanical damage to the cells. Expand
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