The molecular receptive ranges of human TAS2R bitter taste receptors.
The data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs, and some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness.
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
The pharmacological properties of members of the TRPV subfamily are summarized, highlighting the critical issues and challenges facing their “deorphanization” and clinical exploitation.
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia*
- Constance J Chu, Susan M. Huang, J. Walker
- Biology, ChemistryJournal of Biological Chemistry
- 18 April 2003
N-Arachidonoyldopamine (NADA) was recently identified as an endogenous ligand for the vanilloid type 1 receptor (VR1). Further analysis of the bovine striatal extract from which NADA was isolated…
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity.
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
- G. Belcaro, M. Cesarone, G. Appendino
- MedicineAlternative medicine review : a journal of…
- 1 December 2010
Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group, which suggests that Meriva is worth considering for the long-term complementary management of osteoarthritis.
Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation.
The improved absorption, and possibly also a better plasma curcuminoid profile, might underlie the clinical efficacy of Meriva at doses significantly lower than unformulated cur cuminoid mixtures.
Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial
- F. Drobnic, J. Riera, J. Tur
- Medicine, BiologyJournal of the International Society of Sports…
- 18 June 2014
Curcumin has the potential for preventing DOMS, as suggested by its effects on pain intensity and muscle injury, and larger studies are needed to confirm these results and further clarify the mechanism of action of curcumin.
The transient receptor potential channel TRPA1: from gene to pathophysiology
- B. Nilius, G. Appendino, G. Owsianik
- BiologyPflügers Archiv: European Journal of Physiology
- 22 September 2012
Based on localization and functional properties, TRPA1 is considered a key player in acute and chronic (neuropathic) pain and inflammation, and its role in the (patho)physiology of nearly all organ systems is anticipated, and will be discussed along with the potential ofTRPA1 as a drug target for the management of various pathological conditions.
Phytocannabinoids: a unified critical inventory.
- L. Hanuš, Stefan Meyer, E. Muñoz, O. Taglialatela‐Scafati, G. Appendino
- Environmental ScienceNatural product reports (Print)
- 23 November 2016
The integrated inventory of these compounds and their biological macromolecular end-points highlights the opportunities that phytocannabinoids offer to access desirable drug-like space beyond the one associated to the narcotic target CB1.
A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis
- A. G. Granja, F. Carrillo-Salinas, E. Muñoz
- BiologyJournal of Neuroimmune Pharmacology
- 14 September 2012
It is found that VCE-003 ameliorated the symptoms associated to TMEV infection, decreased microglia reactivity and modulated the expression of genes involved in MS pathophysiology, leading us to consider V CE-003 to have high potential for drug development against MS and perhaps other neuroinflammatory diseases.