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The molecular receptive ranges of human TAS2R bitter taste receptors.
The data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs, and some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness. Expand
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
The pharmacological properties of members of the TRPV subfamily are summarized, highlighting the critical issues and challenges facing their “deorphanization” and clinical exploitation. Expand
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia*
N-Arachidonoyldopamine (NADA) was recently identified as an endogenous ligand for the vanilloid type 1 receptor (VR1). Further analysis of the bovine striatal extract from which NADA was isolatedExpand
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
Observations suggest that the prenyl moiety of cannabinoids serves mainly as a modulator of lipid affinity for the olivetol core, a per se poorly active antibacterial pharmacophore, while their high potency definitely suggests a specific, but yet elusive, mechanism of activity. Expand
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group, which suggests that Meriva is worth considering for the long-term complementary management of osteoarthritis. Expand
The transient receptor potential channel TRPA1: from gene to pathophysiology
Based on localization and functional properties, TRPA1 is considered a key player in acute and chronic (neuropathic) pain and inflammation, and its role in the (patho)physiology of nearly all organ systems is anticipated, and will be discussed along with the potential ofTRPA1 as a drug target for the management of various pathological conditions. Expand
Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation.
The improved absorption, and possibly also a better plasma curcuminoid profile, might underlie the clinical efficacy of Meriva at doses significantly lower than unformulated cur cuminoid mixtures. Expand
Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial
Curcumin has the potential for preventing DOMS, as suggested by its effects on pain intensity and muscle injury, and larger studies are needed to confirm these results and further clarify the mechanism of action of curcumin. Expand
Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis.
These results show that Meriva® is clinically effective in the management and treatment of osteoarthritis and suggest that the increased stability and better absorption of curcumin induced by complexation with phospholipids have clinical relevance, setting the stage for larger and more prolonged studies. Expand
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.
The first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid are reported. Expand