Viral immune modulators perturb the human molecular network by common and unique strategies
It is shown that different viral perturbation patterns of the host molecular defence network can be deduced from a mass-spectrometry-based host-factor survey in a defined human cellular system by using 70 innate immune-modulating viORFs from 30 viral species.
Hepatitis c virus and host cell lipids: An intimate connection
HCV exploits lipid metabolism in many ways and may therefore serve as a model system to gain insights into membrane biogenesis, lipid droplet formation and lipid trafficking, suggesting a crucial role for PIPs in viral RNA replication and assembly.
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection.
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62
The findings indicate that in the course of DENV infection, autophagy shifts from a supporting to an antiviral role, which is countered by DENV.
The Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Is Modified by SUMO in a DNA-Dependent Manner
It is shown that overexpression of SUMO alters the intranuclear distribution of UL44 in HCMV-infected cells, and enhances both virus production and DNA replication, arguing for an important role for sumoylation in H CMV life cycle and UL44 function(s).
The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production
A Protein Kinase CK2 Site Flanking the Nuclear Targeting Signal Enhances Nuclear Transport of Human Cytomegalovirus ppUL44
- G. Alvisi, D. Jans, Jin-jin Guo, L. Pinna, A. Ripalti
- BiologyTraffic : the International Journal of…
- 1 November 2005
Examination of ppUL44's nuclear import pathway for the first time reveals a strong nuclear localization in transfected COS‐7 and other cell types, implying that no other HCMV proteins are required for nuclear transportation and retention.
Regulated nucleocytoplasmic trafficking of viral gene products: a therapeutic target?
Tumor-specific nuclear targeting: promises for anti-cancer therapy?
Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells
- H. Kuusisto, K. Wagstaff, G. Alvisi, D. M. Roth, D. Jans
- Biology, PhysicsThe FASEB Journal
- 1 March 2012
Fundamental to eukaryotic cell function, nucleocytoplasmic transport can be regulated at many levels, including through modulation of the importin/exportin (Imp/Exp) nuclear transport machinery…