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Disposition of chloroquine in man after single intravenous and oral doses.
1 Chloroquine was given in 300 mg single doses as an i.v. infusion, an oral solution and as tablets at intervals of at least 56 days to 11 healthy volunteers. Concentrations of chloroquine and itsExpand
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Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
SummaryEuropean data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been collected.No significant difference in phenotype frequencies was foundExpand
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Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamics of tolterodine
To determine whether cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of tolterodine by investigating potential differences in pharmacokinetics and pharmacodynamics (heart rate,Expand
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Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate
AbstractPurpose. The medium chain fatty acid sodium caprate (C10) is approved as an absorption enhancer but its mechanism of action has not been studied in humans. The aim of this study was toExpand
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Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers
In recent years, pharmacokinetic/pharmacodynamic (PK/PD) modeling has developed from an empirical descriptive discipline into a mechanistic science that can be applied at all stages of drugExpand
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Carisoprodol Elimination in Humans
The elimination of the muscle relaxant drug, carisoprodol, was examined in 10 healthy volunteers after an oral dose of 700 mg. In nine subjects, carisoprodol was rapidly eliminated, with a meanExpand
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Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora.
The pharmacokinetics in plasma and saliva of a new ketolide, telithromycin (HMR 3647), and the effect on the normal oropharyngeal and intestinal microflora were studied in healthy volunteers andExpand
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Formation of meprobamate from carisoprodol is catalysed by CYP2C19.
Carisoprodol is a muscle relaxant analgesic, which has an active metabolite i.e. meprobamate. We conducted an open three-panel single-dose administration study with 15 healthy volunteers: five poorExpand
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Clinical pharmacology and the provision of drug information
SummaryClinical pharmacologists have a service role in the provision of drug information to individuals both in hospitals and primary health care. We present here a systematic approach in answeringExpand
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Pharmacokinetics of indomethacin
Plasma concentrations of indomethacin have been studied in 5 healthy volunteers after single and multiple doses (25 mg intravenously [iv], 25, 50, and 100 mg orally, 100 mg rectally, and 25 mg threeExpand
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