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Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for theExpand
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Chromatin dynamics during epigenetic reprogramming in the mouse germ line
A unique feature of the germ cell lineage is the generation of totipotency. A critical event in this context is DNA demethylation and the erasure of parental imprints in mouse primordial germ cellsExpand
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Regulation of Replication Fork Progression Through Histone Supply and Demand
DNA replication in eukaryotes requires nucleosome disruption ahead of the replication fork and reassembly behind. An unresolved issue concerns how histone dynamics are coordinated with forkExpand
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Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
Heterochromatin is thought to play a critical role for centromeric function. However, the respective contributions of the distinct repetitive sequences found in these regions, such as minor and majorExpand
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Chromatin Challenges during DNA Replication and Repair
Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatinExpand
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Epigenetic inheritance during the cell cycle
Studies that concern the mechanism of DNA replication have provided a major framework for understanding genetic transmission through multiple cell cycles. Recent work has begun to gain insight intoExpand
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HP1 and the dynamics of heterochromatin maintenance
Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure the proper segregation of chromosomes and the regulation of gene expression. Although it isExpand
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Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
Post-translational modification of histone tails is thought to modulate higher-order chromatin structure. Combinations of modifications including acetylation, phosphorylation and methylation haveExpand
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Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.
Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRAExpand
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SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin
HP1 enrichment at pericentric heterochromatin is considered important for centromere function. Although HP1 binding to H3K9me3 can explain its accumulation at pericentric heterochromatin, how it isExpand
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