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Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
6-Cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamides were previously disclosed as inhibitors of procollagen C-proteinase (PCP) culminating in the identification of amide 1. Our objective was toExpand
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Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral
1. UK-453,061 is a novel second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Following intravenous bolus administration of UK-453,061 in male rat and infusion administration inExpand
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DISEASES OF THE CORONARY ARTERIES *
  • G. Allan
  • Medicine
  • British medical journal
  • 11 August 1928
mucin could be extracted from the subcutaneous tissues of* these persons. He therefore gave the name of " myxoedema " to supposedly dropsical cases of this type.28 The separation of these cases,Expand
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Social Learning in the Real-World: ‘Over-Imitation’ Occurs in Both Children and Adults Unaware of Participation in an Experiment and Independently of Social Interaction
The current study avoided the typical laboratory context to determine instead whether over-imitation—the disposition to copy even visibly, causally unnecessary actions—occurs in a real-world contextExpand
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Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity
UK-383,367 (5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide) is a novel procollagen C-proteinase inhibitor evaluated for the treatment of post-surgicalExpand
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Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI) which may have potential in treating stress urinary incontinence (SUI). In thisExpand
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A British Medical Association Lecture ON DIABETES MELLITUS AND ITS TREATMENT BY INSULIN
  • G. Allan
  • Medicine
  • British medical journal
  • 12 January 1924
other parts. The combustion of sugar takes place in great part in the muscles, and the glycogen storage depots are called on to supply their needs. During combustion glucose is broken up and excretedExpand
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HAEMOPNEUMOTHORAX WITHOUT TRAUMATISM: RECOVERY
A British Medical Association Lecture on THE EARLY DETECTION AND SUPERVISION OF RHEUMATIC INFECTION IN CHILDREN
IT is now over fouir years since the Section of Medicine atthle Annual Meeting of the British Medical Association at Portsmouth, after a discussion on thle etiology and treatment of heart disease inExpand