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Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells.
Carcinoma-associated fibroblasts (CAF) have recently been implicated in important aspects of epithelial solid tumor biology, such as neoplastic progression, tumor growth, angiogenesis, andExpand
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Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have beenExpand
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Identification of a microRNA panel for clear-cell kidney cancer.
OBJECTIVES To identify a robust panel of microRNA signatures that can classify tumor from normal kidney using microRNA expression levels. Mounting evidence suggests that microRNAs are key players inExpand
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The genomic landscape of pediatric Ewing sarcoma.
UNLABELLED Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven byExpand
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Origin and differentiation of human memory CD8 T cells after vaccination
The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We usedExpand
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In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.
We used an in vivo small hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential forExpand
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Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.
To design successful vaccines for chronic diseases, an understanding of memory CD8(+) T cell responses to persistent antigen restimulation is critical. However, most studies comparing memory andExpand
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Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth.
Triple-negative breast cancers (TNBCs) are a heterogeneous set of cancers that are defined by the absence of hormone receptor expression and HER2 amplification. Here, we found that inducible IκBExpand
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The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification andExpand
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Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma. EWS-FLI1 alters geneExpand
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