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Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.
OBJECTIVE The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification… Expand
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
The results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis. Expand
Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus1
- Jun Zhang, V. Roschke, +6 authors Tong Zhou
- The Journal of Immunology
- 1 January 2001
The results suggest that BLyS may be a useful marker for early activation of an autoimmune diathesis and likely plays a critical role in triggering activation of self-Ag-driven autoimmune B cells in human SLE and may provide an effective therapeutic target in systemic autoimmunity. Expand
Understanding the epidemiology and progression of systemic lupus erythematosus.
- G. Pons-Estel, G. Alarcón, L. Scofield, L. Reinlib, G. Cooper
- Seminars in arthritis and rheumatism
- 1 February 2010
The understanding of ways to improve outcomes in SLE patients could benefit from patient-oriented research focusing on many dimensions of disease burden, and promising research initiatives include the inclusion of community-based patients in longitudinal studies, and use of self-assessment tools for rating disease damage and activity. Expand
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes.
The American College of Rheumatology Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests. Expand
Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness.
Patients with FMS, relative to FMS nonpatients and healthy controls, were characterized by a significantly greater number of lifetime psychiatric diagnoses, and psychiatric disorders are not intrinsically related to the FMS syndrome. Expand
Systemic lupus erythematosus in three ethnic groups: III A comparison of characteristics early in the natural history of the LUMINA cohort
H and AA patients have more active SLE, at an earlier age of onset, and a lessavorable socioeconomic-demographic structure (worse among the H than AA) which predispose them to a less favorable natural history. Expand
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.
- Hitoshi Suzuki, Z. Moldoveanu, +12 authors J. Novak
- Biology, Medicine
- The Journal of clinical investigation
- 1 February 2008
Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked glycans of… Expand
Cancer risk in systemic lupus: an updated international multi-centre cohort study.
There is clearly an increased risk of NHL, and cancers of the vulva, lung, thyroid, and possibly liver in SLE relative to the general population, and it remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Expand
Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels.
The findings of low rCBF and generalized low pain thresholds support the hypothesis that abnormal pain perception in women with FM may result from a functional abnormality within the central nervous system. Expand