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Ethanol modulation of nicotinic acetylcholine receptor currents in cultured cortical neurons.
Ethanol, at physiologically relevant concentrations, significantly enhanced high-affinity neuronal nicotinic acetylcholine receptor (NnAChR) currents insensitive to alpha-bungarotoxinExpand
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Digitalis: new actions for an old drug.
The mechanisms by which digitalis causes its therapeutic and toxic actions have been studied for nearly a half century, revealing a great deal about cardiac cell regulation of intracellular ions viaExpand
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Variability in Timing of Spontaneous Calcium Release in the Intact Rat Heart Is Determined by the Time Course of Sarcoplasmic Reticulum Calcium Load
Background: Abnormalities in intracellular calcium (Ca) cycling during Ca overload can cause triggered activity because spontaneous calcium release (SCR) activates sufficient Ca-sensitive inwardExpand
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Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol
Controversies remain over which ion channels are the most sensitive to ethanol. We have found that ethanol potently modulates the neuronal nicotinic acetylcholine receptor-channel at micromolarExpand
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Neuronal nicotinic acetylcholine receptors: a new target site of ethanol
Whereas a variety of neuroreceptors and ion channels have been demonstrated to be affected by ethanol including GABAA receptors, NMDA receptors, non-NMDA glutamate receptors, 5-HT3 receptors andExpand
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Ouabain Increases Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes
The inotropic and toxic effects of cardiac glycosides are thought to be related to their ability to inhibit the Na,K-ATPase. We examined the effects of ouabain and its analogs on sarcoplasmicExpand
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Dual action of n-alcohols on neuronal nicotinic acetylcholine receptors.
Alcohol is known to modulate the activity of a variety of neuroreceptors and ion channels. Recently, neuronal nicotinic acetylcholine receptors (nnAChRs) have become a specific focus of study becauseExpand
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Ethanol modulation of excitatory and inhibitory synaptic interactions in cultured cortical neurons.
The effects of ethanol on spontaneous excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) were studied in a culture of embryonic rat cortical neurons. In these experiments, EPSCs andExpand
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Mechanisms Underlying the Formation and Dynamics of Subcellular Calcium Alternans in the Intact Rat Heart
Optical mapping of intact cardiac tissue reveals that, in some cases, intracellular calcium (Ca) release can alternate from one beat to the next in a large-small-large sequence, also referred to asExpand
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Intracellular Ca2+ waves, afterdepolarizations, and triggered arrhythmias.
Clinical studies have shown that sudden death is initiated by an ill-timed propagated ectopic beat that leads to fibrillation.1–4 However, the mechanism underlying these focal excitations is notExpand
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