• Publications
  • Influence
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
TLDR
It is suggested that NPs promote "browning" of white adipocytes to increase energy expenditure, defining the heart as a central regulator of adipose tissue biology. Expand
microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma.
TLDR
It is demonstrated that miR-27b abundance decreased during adipogenesis of human multipotent adipose-derived stem (hMADS) cells, and suggested that the anti-adipogenic effect of miR -27b in hMADS cells is due, at least in part, to suppression of PPARgamma. Expand
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
TLDR
The issue of the high content of linoleic acid of ingested lipids during pregnancy and lactation, and formula milk and infant foods in relation to the epidemic of childhood obesity is raised. Expand
Differentiation of embryonic stem cells into adipocytes in vitro.
TLDR
The differentiation of embryonic stem cells into adipocytes will provide an invaluable model for the characterisation of the role of genes expressed during the adipocyte development programme and for the identification of new adipogenic regulatory genes. Expand
Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse
TLDR
The results suggest that hMADS cells will be an important tool for muscle cell–mediated therapy based on the small amounts of an easily available tissue source, their strong capacity for expansion ex vivo, their multipotent differentiation, and their immune-privileged behavior. Expand
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.
TLDR
In db/db and lesioned mice, quantitative differences in expression level of ob RNA correlated with adipocyte lipid content, suggesting that both the db gene and the hypothalamus are downstream of the ob gene in the pathway that regulates adipose tissue mass. Expand
Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins beta and -delta in preadipocytes.
TLDR
These findings suggest that ERK activation is required for CREB transcriptional activity, possibly by recruitment of a coactivator, and both pathways share cAMP responsive element binding protein/activation transcription factor 1 (CREB/ATF-1) as common downstream effectors. Expand
Compactin enhances osteogenesis in murine embryonic stem cells.
TLDR
It is shown that retinoic acid is important for the commitment of ES cells into osteoblasts and established ES-cell derived osteogenesis as an effective model system to study the molecular mechanisms by which the statin compactin promotes osteoblastic differentiation and bone nodule formation. Expand
A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations[S]
TLDR
It is shown that a Western-like fat diet induces a gradual fat mass enhancement, in accordance with the increasing prevalence of obesity observed in humans. Expand
Delta-interacting Protein A, a New Inhibitory Partner of CCAAT/Enhancer-binding Protein β, Implicated in Adipocyte Differentiation*
TLDR
DIPA is a novel partner of C/EBPβ that down-regulates early events of adipogenesis, and overexpression of DIPA in preadipocytes results in a partial inhibition of the mitotic clonal expansion which is critical for differentiation. Expand
...
1
2
3
4
5
...