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Dissecting the Pre-Columbian Genomic Ancestry of Native Americans along the Andes–Amazonia Divide
TLDR
The results support the hypothesis that all non-Andean South Americans are compatible with descending from a common lineage, while low support for common Mesoamerican ancestors of both Andeans and other South American groups is found. Expand
The genomic impact of European colonization of the Americas
TLDR
A genome-wide dataset is compiled and a high degree of complexity underlying the genetic contribution of European and African populations in North and South America is revealed, identifying previously unreported sources related to Italy, the Middle East and to specific regions of Africa. Expand
The Genomic Impact of European Colonization of the Americas
TLDR
A genome-wide dataset is compiled and haplotype-based methods applied to investigate how historical movements from outside the New World affected the genetic structure, the admixture profile, the demographic history, and the sex-biased gene-flow dynamics of the Americas. Expand
Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans
TLDR
The contribution of multiple migratory and adaptive events in shaping the heterogeneous Italian genomic background is disentangled, which exemplify population dynamics and gene-environment interactions that played significant roles also in the formation of the Continental and Southern European genomic landscapes. Expand
Evidence of Polygenic Adaptation to High Altitude from Tibetan and Sherpa Genomes
TLDR
The findings pinpointed a series of selective events neglected so far, which likely contributed to the augmented tissue blood perfusion observed in Tibetans and Sherpa, thus uncovering the genetic determinants of a key biological mechanism that underlies their adaptation to high altitude. Expand
Gut microbiota composition in Himalayan and Andean populations and its relationship with diet, lifestyle and adaptation to the high-altitude environment.
TLDR
The collected evidences suggest that microbial signatures associated to these rural populations may enhance metabolic functions able to supply essential compounds useful for the host to cope with high altitude-related physiological changes and energy demand. Expand
Ancient genomic time transect from the Central Asian Steppe unravels the history of the Scythians
TLDR
Genome-wide data for 111 ancient individuals retrieved from 39 archaeological sites from the first millennia BCE and CE across the Central Asian Steppe uncovered major admixture events in the Late Bronze Age forming the genetic substratum for two main Iron Age gene- pools emerging around the Altai and the Urals respectively. Expand
The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas
TLDR
These findings improved the understanding of the impact of gene flow/drift on the evolution of high-altitude Himalayan peoples and shed light on migration events that drove colonization of the southern Himalayan slopes, as well as on the role played by different Tibeto-Burman groups in such a complex demographic scenario. Expand
Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
TLDR
Comparing adaptive evolution of East Asian and South Asian populations with that of control groups from regions where the adoption of cereal‐based diets occurred many thousand years later revealed selective sweeps and polygenic adaptive mechanisms affecting functional pathways involved in fatty acids metabolism, cholesterol/triglycerides biosynthesis from carbohydrates, regulation of glucose homeostasis, and production of retinoic acid in Chinese Han and Tujia ethnic groups. Expand
Ten millennia of hepatitis B virus evolution
TLDR
The most recent common ancestor of all HBV lineages is dated to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. Expand
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