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Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
After apoptosis, phagocytes prevent inflammation and tissue damage by the uptake and removal of dead cells. In addition, apoptotic cells evoke an anti-inflammatory response through macrophages. WeExpand
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Macrophage Interactions with Neutrophils Regulate Leishmania major Infection1
Macrophages are host cells for the pathogenic parasite Leishmania major. Neutrophils die and are ingested by macrophages in the tissues. We investigated the role of macrophage interactions withExpand
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  • Open Access
Neutrophils Activate Macrophages for Intracellular Killing of Leishmania major through Recruitment of TLR4 by Neutrophil Elastase1
We investigated the role of neutrophil elastase (NE) in interactions between murine inflammatory neutrophils and macrophages infected with the parasite Leishmania major. A blocker peptide specificExpand
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Apoptosis underlies immunopathogenic mechanisms in acute silicosis.
We investigated immunopathogenic roles for apoptosis in acute murine silicosis. Intratracheal silica instillation induced pulmonary inflammation and enlarged thoracic lymph nodes. Lymphocytes fromExpand
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Activation-induced CD4+ T cell death by apoptosis in experimental Chagas' disease.
Infection of mice with Trypanosoma cruzi, the causative protozoan agent of human Chagas' disease, leads to immunosuppression of the T cell compartment and to chronic cardiac inflammation whichExpand
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Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology.
The pathogenic protozoan parasite Trypanosoma cruzi expresses on its surface an unusual family of glycoinositolphospholipids (GIPLs) closely related to glycosylphosphatidylinositol (GPI) anchors.Expand
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Induction of autophagy correlates with increased parasite load of Leishmania amazonensis in BALB/c but not C57BL/6 macrophages.
We investigated the role of autophagy in infection of macrophages by Leishmania amazonensis. Induction of autophagy by IFN-gamma or starvation increased intracellular parasite load and theExpand
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Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages
Clearance of apoptotic exudate neutrophils (efferocytosis) induces either pro- or anti-inflammatory responses in mouse macrophages depending on host genetic background. In this study, we investigatedExpand
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TGF-β Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar1
Recent studies indicate important roles for CTLA-4 engagement in T cells, and for TGF-β production in the immunopathogenesis of murine kalaazar or visceral leishmaniasis, but a functional linkExpand
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FAS Ligand Triggers Pulmonary Silicosis
We investigated the role of Fas ligand in murine silicosis. Wild-type mice instilled with silica developed severe pulmonary inflammation, with local production of tumor necrosis factor (TNF)-α, andExpand
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  • Open Access