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Pharmacological Preconditioning With Tumor Necrosis Factor-α Activates Signal Transducer and Activator of Transcription-3 at Reperfusion Without Involving Classic Prosurvival Kinases (Akt and
This work shows the existence of an alternative protective pathway that involves STAT-3 activation specifically at reperfusion in response to both TNF-α and classic IPC, and this novel prosurvival pathway may have potential therapeutic significance.
Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension
Pulmonary hemodynamics and the development of hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in mice overexpressing the gene for the 5-HT transporter are investigated, providing a unique model that demonstrates differential mechanisms for familial pulmonary arterial hypertension and lungs with hypoxemia.
Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin‐1 in the control of pulmonary vascular tone
It is demonstrated that basal NO activity masks a pulmonary pressor response to exogenously administered endothelin‐1, implicating a pathophysiological role for ET‐1 in this model of pulmonary hypertension.
Influence of 100% and 40% Oxygen on Penumbral Blood Flow, Oxygen Level, and T*2-Weighted MRI in a Rat Stroke Model
For diagnostic imaging, 40% O2 OC could provide sufficient T*2 signal change to detect penumbra with limited influence in BP and CBF and determined the effects on blood pressure, CBF, tissue pO2, and T*1 signal change in presumed penumbr in a rat stroke model.
Pulmonary responses to 5-hydroxytryptamine and endothelin-1 in a rabbit model of left ventricular dysfunction.
In the rabbit, LVD secondary to coronary artery ligation, causes right ventricular hypertrophy, pulmonary vascular remodelling, and an increased PAP consistent with the onset of pulmonary hypertension (PHT), which supports the hypothesis that this substance could be involved in the development of PHT.
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)
Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to
Perfluorocarbons Enhance a T2*-Based MRI Technique for Identifying the Penumbra in a Rat Model of Acute Ischemic Stroke
It is investigated whether an oxygen-carrying perfluorocarbon (PFC) emulsion can enhance the sensitivity of the T2*OC technique, enabling penumbra detection with lower levels of inspired oxygen, and region of interest analyses between groups showed that PFC significantly enhanced the T1* response to 40% O2 in T2-defined penumbRA.
11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice.
Loss of 11β-HSD2 leads to striking atherogenesis associated with activation of MR, stimulating proinflammatory processes in the endothelium of E/b2 mice.
TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning.
Exogenous TNFalpha mimics IPC by providing a dose-dependent cardioprotective effect against ischaemia-reperfusion injury in vivo and dose-dependently reduced IS with maximal protection at a dose of 0.1 microg/kg.
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke
The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two