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The acute effects of single intravenous or oral doses of indenolol, as compared to that of propranolol and pindolol, on systemic blood pressure and heart rate were investigated in the rat. In reserpinized anaesthetized rats propranolol neither affected diastolic blood pressure nor heart rate and pindolol produced a dose-related tachycardia with moderate(More)
We have investigated the changes in airway reactivity induced in guinea-pigs by passive cigarette smoke exposure. In particular, we studied the development of airway hyperresponsiveness both in vivo and in vitro after passive exposure of the animals to cigarette smoke in a plexiglass box. Passive smoke exposure significantly (p less than 0.01) increased(More)
Environmental exposure to tobacco smoke contributes to the onset of several lung diseases, e.g. chronic bronchitis and asthma, including an increase in airway reactivity. We have investigated the effect of a new mucoactive compound, CO 1408, on airway hyperreactivity and lung inflammation induced in guinea-pigs by passive cigarette smoke exposure. Animals(More)
The pharmacological activity and acute toxicity of (-)-6(S)-hydroxy-4(R)-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol (CO/1408, CAS 103079-06-7), a new mucoactive drug, were evaluated. After oral and intravenous administration CO/1408 increased the pulmonary secretion of fluorescein in rats, as an index of bronchosecretogogue activity. In addition,(More)
The antianaphylactic activity of inhaled frusemide was studied in ovalbumin-sensitized guinea-pigs. The exposure of the animals to frusemide aerosol (1% solution for 20 min) attenuated the respiratory response to ovalbumin challenge (aerosol 1% solution) and was associated with a significant reduction of blood histamine (70%; P less than 0.01) and(More)
The inhibition of the production of malonyldialdehyde (MDA) in guinea-pig lung homogenates, incubated in the presence of 50 microM arachidonic acid and 1.4 mM adrenaline, has been exploited as a simple and reliable assay to test in vitro non-steroidal anti-inflammatory agents (NSAIA). The inhibitory potencies of a series of reference NSAIA, which correlated(More)
The effect of esaprazole, a new antiulcer compound endowed with gastro-protective properties, on rat gastric mucus was investigated after acute oral administration. Both soluble (luminal) and insoluble (parietal) mucus were examined for their content of: acidic and neutral glycoproteins; N-acetylneuraminic acid by colorimetric techniques; and fucose by HPLC(More)
Esaprazole, N-cyclohexyl-1-piperazineacetamide monohydrochloride, was studied for its activity to prevent gastric mucosal damage induced by several necrotizing agents in the rat. Its effects on acid gastric secretion and the role of gastric mucosal prostaglandin generation were also investigated. Esaprazole, given orally, dose dependently prevented the(More)
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