G Wayne Brodland

Learn More
The polymeric split Hopkinson pressure bar (PSHPB) apparatus is introduced as a means for measuring the high strain rate (1,000-2,500 s(-1)) compressive properties of soft tissues. Issues related to specimen design are discussed, and protocols are presented for specimen preparation. Proposed specimen geometries were validated using high-speed photography.(More)
The biomechanical environment of the optic nerve head (ONH), of interest in glaucoma, is strongly affected by the biomechanical properties of sclera. However, there is a paucity of information about the variation of scleral mechanical properties within eyes and between individuals. We thus used biaxial testing to measure scleral stiffness in human eyes. Ten(More)
Theoretical, numerical and experimental methods are used to develop a comprehensive understanding of how cell shape affects the mechanical characteristics of two-dimensional aggregates such as epithelia. This is an important step in relating the mechanical properties of tissues to those of the cells of which they are composed. Statistical mechanics is used(More)
Delamination between lamellae of the annulus fibrosus is a crucial stage of intervertebral disc herniation, and to better understand the mechanics of the delamination process, a novel lap test was devised. Specimens consisting of two adjacent, naturally bonded lamellae were obtained from the cervical region of frozen porcine spines. They were cut into(More)
Although computer simulations indicate that mitosis may be important to the mechanics of morphogenetic movements, algorithms to identify mitoses in bright field images of embryonic epithelia have not previously been available. Here, the authors present an algorithm that identifies mitoses and their orientations based on the motion field between successive(More)
Although cell reshaping is fundamental to the mechanics of epithelia, technical barriers have prevented the methods of mechanics from being used to investigate it. These barriers have recently been overcome by the cell-based finite element formulation of Chen and Brodland. Here, parameters to describe the fabric of an epithelium in terms of cell shape and(More)
  • 1