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BACKGROUND Wide testing of the aldosterone : renin ratio among hypertensive individuals has revealed primary aldosteronism to be common, with most patients normokalaemic. Some investigators, however, have reported aldosterone-producing adenoma to be rare among patients so detected. OBJECTIVE To test the hypothesis that differences among reported studies(More)
Changes in cortisol metabolism due to altered activity of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) have been implicated in the pathogenesis of hypertension, obesity and the metabolic syndrome. No published data exist on the activity of this enzyme in critical illness. To investigate cortisol metabolism in critically ill patients utilising(More)
BACKGROUND Because primary aldosteronism is not uncommon, specifically treatable and in some cases curable, and carries higher risks for cardiovascular morbidity and mortality than essential hypertension, screening hypertensive patients for its presence by measuring aldosterone to renin ratio (ARR) is increasingly common. A significantly higher(More)
0. Introduction. Attempts have been made to place restrictions on the morphological and/or semantic types of constituents which can be preposed via Topicalization. In particular, it has been claimed that certain types of indefinite NPs cannot be preposed. For example, it has been claimed only specific indefinites can be preposed, that only nonspecific(More)
It is increasingly recognized in Natural Language Processing that intonation makes a significant contribution to the communication of discourse structure. However, the correspondence between particular intonational features and specific aspects of discourse structure is only beginning to be understood. In this paper, we show how tune, phrasing, accent, and(More)
OBJECTIVES To explore whether aldosterone excess can induce adverse cardiovascular effects independently of effects on blood pressure (BP), we sought evidence of disturbed cardiovascular structure or function in normotensive individuals with primary aldosteronism. METHODS Eight normotensive subjects with genetically proven familial hyperaldosteronism type(More)
BACKGROUND The most popular screening test for primary aldosteronism is plasma aldosterone/renin ratio (ARR). Because both estrogen and progesterone affect aldosterone and renin levels, we studied effects of two contraceptives commonly used in our population, one oral and one subdermal, on ARR, measuring renin as both direct renin concentration (DRC) and(More)
To compare the total plasma cortisol values obtained from three widely used immunoassays and a high pressure liquid chromatography (HPLC) technique on samples obtained from patients with sepsis. Observational interventional in the general intensive care unit of a metropolitan hospital Patients admitted to the intensive care unit with a diagnosis of sepsis(More)
BACKGROUND The most popular screening test for primary aldosteronism (PAL) is the plasma aldosterone to renin ratio (ARR). Medications, dietary sodium, posture, and time of day all affect renin and aldosterone levels and can result in false-negative or -positive ARR if not controlled. Opinions are divided on whether beta-adrenoreceptor blockers(More)