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The metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3 dicarboxylic acid (ACPD) at concentrations above 60 microM produced stereotypic oscillatory activity in CA3 pyramidal cells of rat hippocampal slices. This oscillatory activity consisted of trains of depolarizations with overriding action potentials. On average, individual trains(More)
BACKGROUND Reduced power and phase locking of the early auditory gamma-band response (EAGBR) have been reported in schizophrenia, but findings are equivocal. Further, little is known about genetic (heritability) and environmental influences on the EAGBR or its potential as an endophenotype of schizophrenia. The present study used a twin design to examine(More)
Historically, bipolar disorder and schizophrenia have been considered distinct disorders with different etiologies. Growing evidence suggests that overlapping genetic influences contribute to risk for these disorders and that each disease is genetically heterogeneous. Using cluster analytic methods, we empirically identified homogeneous subgroups of(More)
Information is stored in distributed cortical networks, but it is unclear how distributed stores are synthesized into a unified percept. Activation of local circuits in the gamma range (30 < < 80 Hz), and distributed stores in the low theta range (3-5 Hz) may underlie perceptual binding. Words have a crucial role in semantic memory. Within memory, the(More)
1. Epileptiform activities were elicited from the in vitro guinea pig hippocampus by the addition of picrotoxin. Modification of the picrotoxin-induced activities by agents active at metabotropic glutamate receptors (mGluRs) was examined using intracellular and extracellular recordings. 2. Picrotoxin typically elicited synchronized discharges (epileptiform(More)
Considerable information is available regarding the role of ionotropic glutamate receptors in the generation of interictal spikes. Progress in the study of metabotropic glutamate receptors (mGluRs) makes clear that activation of these receptors can contribute greatly to seizure discharges and epileptogenesis. The effects of activation of the different mGluR(More)
BACKGROUND The P50 event-related potential sensory gating deficit, a failure to inhibit responses to repeated stimuli, is a leading endophenotype for schizophrenia (SZ). Both gamma and beta event-related oscillations (EROs) are major contributors to the auditory P50 response. However, the topographic distribution of gamma and beta ERO responses to initial(More)
BACKGROUND Abnormalities in coherent cortical circuit functioning, reflected in gamma band activity (to approximately 40 Hz), may be a core deficit in schizophrenia. The early auditory gamma band response (EAGBR) is a neurophysiologically simple probe of circuit functioning in primary auditory cortex. We examined the EAGBR in first hospitalized(More)
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