G W Botteron

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Atrial fibrillation (AF) is a common clinical problem, associated with considerable morbidity and mortality, for which effective management strategies have yet to be devised. The absence of objective measures to guide selection of antiarrhythmic drug therapy for maintenance of sinus rhythm leaves only clinical endpoints (either beneficial or detrimental)(More)
UNLABELLED The standard ECG correlates poorly with LV mass. The SAECG precisely measures myocardial energy and may allow more exact noninvasive assessment of LV mass. A commercially available system (Corazonix Predictor I) was tested for its ability to reproduce and measure known input energy in square wave and QRS waveforms, using frequency bandwidths(More)
UNLABELLED Internal Cardioversion. INTRODUCTION This report describes the electrical conversion of atrial fibrillation in two morbidly obese patients refractory to external cardioversion at 360 J. METHODS AND RESULTS The two patients were lightly sedated and underwent placement of decapolar catheters in the coronary sinus and right atrial appendage. All(More)
BACKGROUND Atrial activation during atrial fibrillation (AF) is frequently described as random or chaotic. We propose that activation during AF is constrained by the principles of reentrant excitation; that these constraints impart a measurable spatial organization to activation during AF; and that the distance over which activation sequences remain well(More)
INTRODUCTION Adenosine is an antiarrhythmic agent widely used for the diagnosis and treatment of supraventricular tachyarrhythmias. Bolus administration of adenosine has been associated with transient atrial fibrillation, but the underlying mechanisms have not yet been delineated, due in part to the technical limitations resulting from adenosine's short(More)
The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days. Mexiletine hydrochloride, 200 mg every 8 hours, was given for(More)
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