G. V. Sherbet

M. Wildridge1
A. L. Harris1
J. R. Farndon1
1M. Wildridge
1A. L. Harris
1J. R. Farndon
1A. L. Latner
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The high molecular weight form of the plasminogen activator urokinase (54 kD) binds to specific receptor sites on the cell membrane of breast carcinomas by its inactive "A" chain. The binding is of high affinity (range of dissociation constants: 5.6 X 10(-11) to 4 X 10(-10) mol l-1 and there were between 20 to 250 fmol of binding sites per milligram of(More)
Present evidence suggests that the cell surface has an important role in metastasis. To examine this idea further, the surface properties of single cells isolated from the primary growths of a liver-metastasizing (ML) and a non-metastasizing (NML) lymphosarcoma were compared for adhesion to cell monolayers, cytopherometry, isoelectric focusing, adhesion to(More)
—The presence of metastasis in the regional lymph nodes is the most important factor in predicting prognosis in breast cancer. Many biomarkers have been identified that appear to relate to the aggressive behaviour of cancer. However, the nonlinear relation of these markers to nodal status and also the existence of complex interaction between markers has(More)
THE IMPORTANCE of tumour markers for the detection of malignancies, and for determining the extent and the clinical course of the disease, has prompted much investigation into the establishment of possible biochemical markers for breast cancer. Although tumour-associated products such as the carcinoembryonic anti-gen (Wang et al., 1975; Tormey et al.,(More)
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