G. V. Kornilaeva

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To investigate the mechanism of action of the 22-amino-acid HIV fusion peptide on HIV infection, we studied its influence on virus adsorption and HIV-induced syncytium formation. The effect of the peptide preparations on the synthesis of viral antigens in HIV-infected cell cultures was determined by antigen capture assay, and the inhibition of proviral DNA(More)
The ganglioside composition of Ehrlich ascites carcinoma (EAC) cells and the role of the individual gangliosides in binding and penetration into the cell of influenza virus were determined. EAC gangliosides identical with or close to GM3, GM2, GM1, GT1a and GT1b were characterized by thin-layer chromarography, compositional analyses, methylation analysis(More)
The capacity of two gangliosides, GD1a and GT1b isolated from bovine brain to function as specific receptors of influenza virus was determined. A primary chick fibroblast culture was treated with neuraminidase to destroy natural receptors, the cells were loaded with gangliosides GD1a and GT1b, inoculated with 3H-uridine-labeled virus, and virus adsorption(More)
Ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide, isolated from extracts of garlic (Allium sativum) has been previously shown to inhibit platelet aggregation by inactivating allosterically the platelet integrin, GP IIb/IIIa. The structural and functional similarity of integrins led the authors to suggest that ajoene may also inhibit adhesive(More)
The mechanism of antiviral activity of the CD4-derived peptide 75-99 was compared with that of sulfated polysaccharides. A set of peptides representing all the high positive charge density regions of gp120 and gp41 was used to determine whether electrostatic interactions occur between these negatively charged agents and positively charged HIV envelope(More)
5'-Phosphites (5'-hydrogenphosphonates) of 3'-azido-2'-, 3'-dideoxynucleosides are shown to be effective inhibitors of the human immunodeficiency virus (HIV-1) in MT4 cell culture. 5'-Phosphite of 3'-azido-2', 3'-dideoxythymidine was the most active among these compounds and even a little more active as compared to the well-known anti-AIDS drug(More)
I t has been reported earlier tha t some chemicals (ethylenimine, N-nitrosomethylurea, O-methylhydroxylamine) and UV-radiat ion were effective in induct ion of plaque mutan t s in the Weybridge strain of F P V (1, 2, 3). The spontaneous and induced mutan t s isolated from an original large plaque var iant of F P V were grouped according to their biological(More)