G. Udvardi

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K-ras codon 12 mutations are an early event in pancreatic carcinogenesis. However more than 1 in 1000 cells have to be mutated and other (additional?) mutations may be necessary for the development of pancreatic neoplasia. Only long term studies will provide insight into the clinical significance of K-ras gene mutations in chronic pancreatitis.
Reported on an oral hydrochloric acid erosion in addition to an intoxication with a narcotic drug. The patient recovered very quickly from the narcotic drug intoxication but developed pyloric obstruction within a few weeks. Only a Billroth II operation was able to restore a sufficient gastrointestinal function.