G. Spillantini

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Lung involvement was studied by perfusion scan, ventilation scan, pulmonary clearance rate of 99mTc DTPA and pulmonary function tests in 20 patients with systemic sclerosis (SSc). Decreased plasma angiotensin converting enzyme (ACE) activity and increased levels of von Willebrand Factor Antigen (vWF:Ag) were found in all patients with SSc. The relationship(More)
Decreased levels of angiotensin converting enzyme plasma activity were found in systemic sclerosis. No relationship with clinical characteristics of the disease and increased von Willebrand factor antigen concentration (a widely accepted marker of endothelial injury) were statistically demonstrated. An inverse relationship between the reduced activity of(More)
Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II (1) and plays a fundamental role in bradykinin degradation (2). It is localized in vascular endothelial cells (3), predominantly in the capillaries of the lung (4). It has been supposed that the variation of the levels of ACE might provide a marker of endothelial(More)
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