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The effects of three aminoglycoside antibiotics on the rat isolated phrenic nerve-diaphragm preparation and on the sciatic nerve-gastrocnemius muscle preparation were investigated. Tobramycin, amikacin and ribostamycin produced dose-dependent neuromuscular blockade of the diaphragm twitches. Comparison of results showed that the neuromuscular blocking… (More)
Muscimol and diazepam reduced the number of avoidance responses of rats subjected to a conditioned avoidance situation. Diazepam, in a dose which per se did not influence the conditioned responses, significantly increased the disruption of avoidance behavior induced by muscimol. Bicuculline counteracted the avoidance impairment produced by muscimol, whereas… (More)
O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1----6)-O-[2,6-diamino-2,3,4,6 -tetradeoxy-alpha-D-erythro-hexopyrano-hexopyranosyl-(1----4 ) ]-2-deoxy-L- streptamine (dibekacin), like other known aminoglycoside antibiotics, possesses a dose-dependent neuromuscular blocking activity in vivo. d-Tubocurarine, at a dose which per se does not influence the… (More)
Lidocaine hydrochloride and lidocaine salicylate (lisacaine) have been tested on the frog node of Ranvier, on the sheep cardiac Purkinje fibres and rat phrenic nerve-diaphragm. On the node of Ranvier both drugs produced the same degree of reduction of peak INa and steady-state potassium current and the same degree of shift of the steady-state inactivation… (More)
The effect of acute administration of rifampicin on neuromuscular transmission was tested, in-vivo, in the rat. Rifampicin did not alter the strength of contraction of the muscle indirectly stimulated at various frequencies. Additional isoniazid pretreatment did not alter the absence of effect of rifampicin on neuromuscular action.
2'-Amino-2'-deoxy-kanamycin (bekanamycin, Kanendomycin) and pentisomicin displayed a neuromuscular blocking activity on the rat sciatic nerve-gastrocnemius muscle preparation. Pentisomicin showed the highest neuromuscular blocking effect; the neuromuscular blocking potency of bekanamycin was similar to that of tobramycin, another new aminoglycoside. The… (More)
1 The present study aimed to evaluate the role of kappa-opioid receptors at two peripheral sites, the vas deferens and the proximal colon, in kappa-opioid receptor knockout mice. We investigated the role of the kappa-opioid receptor in the vas deferens twitch response and in the colonic "off-contraction", a rebound contractile response which follows the… (More)