G S Antonarakis

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In vertebrates, face and throat structures, such as jaw, hyoid and thyroid cartilages develop from a rostrocaudal metameric series of pharyngeal arches, colonized by cranial neural crest cells (NCCs). Colinear Hox gene expression patterns underlie arch specific morphologies, with the exception of the first (mandibular) arch, which is devoid of any Hox gene(More)
Nonsyndromic cleft lip with or without cleft palate (CL-P) is a common congenital anomaly with incidence ranging from 1 in 300 to 1 in 2,500 live births. We analyzed two Indian pedigrees (UR017 and UR019) with isolated, nonsyndromic CL-P, in which the anomaly segregates as an autosomal dominant trait. The phenotype was variable, ranging from unilateral to(More)
PURPOSE To evaluate the long-term cost-effectiveness of five treatment alternatives for maxillary lateral incisor agenesis where space maintenance and tooth replacement are indicated. MATERIALS AND METHODS The following treatment modalities were considered: single-tooth implant-supported crown, resin-bonded fixed partial denture (FPD), cantilever FPD,(More)
OBJECTIVE To investigate the nature and readability of cleft lip and palate-related family information on the Internet. MATERIALS AND METHODS An Internet search for "cleft lip," "cleft palate," and "family information" was carried out using three search engines. Within each search, the first 25 relevant websites identified were downloaded and assessed for(More)
OBJECTIVE To use published data to evaluate quantitatively the dental effects of noncompliance intramaxillary appliances in individuals with Class II malocclusion. MATERIALS AND METHODS A literature search was carried out identifing 13 prospective or retrospective clinical studies matching inclusion criteria. Only appliances with conventional anchorage(More)
THE OBJECTIVE To evaluate oral health-related quality of life (OHRQoL) in non-syndromic patients with cleft lip and/or palate (CLP), in comparison to a general non-cleft population. BASIC RESEARCH DESIGN Systematic review. A literature search was conducted to identify papers reporting on OHRQoL in cleft samples. Only studies with suitable control groups(More)
PURPOSE To evaluate vertical stability after combined orthodontic surgical treatment of skeletal anterior open-bite malocclusion. MATERIALS AND METHODS A literature search was performed to locate studies pertaining to vertical stability after combined orthodontic surgical treatment of skeletal anterior open-bite malocclusion. Data from the identified(More)
INTRODUCTION Individuals with Pierre Robin sequence (PRS) frequently have tooth agenesis, especially in the mandible. The aims of this study were to characterize permanent tooth agenesis patterns and to determine their prevalence in patients with nonsyndromic PRS. METHODS Radiographs and clinic charts of 146 children with nonsyndromic PRS were examined(More)
Recent research indicates that control of cusp morphology involves a signalling center at the heart of the developing tooth germ, known as the enamel knot. The primary enamel knot forms in both incisors and molar tooth germs at the cap stage of tooth development. Secondary and tertiary enamel knots only develop in molar tooth germs. These sit at the sites(More)
Toothwear cases can vary dramatically in their presentation, with some displaying quite peculiar patterns. This case report outlines a patient's unusual eating habit that had led to a localized pattern of toothwear affecting his maxillary and mandibular central incisors. The patient had a habit of eating fresh chillies between his incisors after most(More)