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Expression of prostaglandin-H-synthase (PGHS) isozymes was analyzed in 50 biopsies of normal human skin and of pre-malignant and malignant skin lesions, by means of quantitative RT-PCR, immunoprecipitation and Western blotting, as well as immunohistochemistry. Normal skin constitutively expressed PGHS-1 in all cell layers of the epidermis, in endothelial(More)
The aim of the present study was to evaluate the influence of titanium-coated polymers on the inflammatory response and remodeling of connective tissue during wound-healing processes. Discs of polyethyleneterephthalate (PET) and silicone as well as high-weight meshes of polypropylene (PP) were coated with a titaniumcarboxonitride (Ti(C,N,O)) layer by a(More)
Today, there is a consensus that melanocytic nevi must not be removed by means of destructive modalities such as laser or electrodessication, since these procedures preclude histopathologic evaluation and may mask malignant transformation. Hence, a surgical excision with subsequent histopathologic evaluation remains the gold standard. Yet, patients that(More)
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