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The phosphatidylinositol (PI) 3-kinase/Akt signaling pathway has a prominent role in cell survival and proliferation, in part, by regulating gene expression at the transcriptional level. Previous work using global expression profiling identified FOXOs and the E-box-binding transcription factors MITF and USF1 as key targets of PI 3-kinase signaling that lead(More)
Early diagnosis of precancerous and malignant lesions is critical for the improving of the current poor survival rate of patients with a variety of tumors. The development of new high-specificity and high-sensitivity imaging technologies can play an important role in the early diagnosis, accurate staging, and treatment of cancer. Bio-optical signals are the(More)
Early diagnosis of precancerous and malignant lesions is critical for the improving of the current poor survival rate of patients with a variety of tumors. The development of new high-specificity and high-sensitivity imaging technologies can play an important role in the early diagnosis, accurate staging, and treatment of cancer. Bio-optical signals are the(More)
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