G. N. Fedorov

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It has been shown that trophoblastic beta 1-glycoprotein (TBG) and placental alpha 2-microglobulin (PAMG-2) in concentrations 60-120 micrograms/ml suppresses both the inductive and proliferative phase of unidirectional mixed lymphocyte reaction in mice, as well as proliferative responses to phytohemagglutinin or pokeweed mitogen. TBG protein was more(More)
Mechanisms of various kinds of pathology can be studied on a model of the graft versus host reaction (GVHR): autoimmune diseases, lymphoproliferative processes, and immunodeficiency states [I, 6, 7]. The pathogenesis of G\~R itself has not been fully explained. In particular, the role of the endocrine system in the development of GVHR has not been studied.(More)
The placenta is considered to play the principal role in the prevention of rejection of a genetically foreign fetus in mammals. In recent years the immunoregulatory properties of various substances produced by the?placenta have therefore been extensively investigated [4, 15]. The present writers have isolated and highly purified two new proteins specific(More)
The liver has a detoxifying function in the body, it takes part in protein, hormone, and vitamin metabolism, it acts in the embryonic period as a hematopoietic organ, it regulates the blood erythropoietin level, and serves as a blood depot [i]. The role of the liver in immunologic reactions and, in particular, in transplantation immunity has not yet been(More)
Different strains of mice CBA (H-2k) and C57BL/6 (H-2b) have been exposed to burn of flame of 15% skin-deep of body. Spleen cells were received 6 hours, 3 and 7 days after burn trauma of mice in order to induce the local graft-versus-host reaction by subcutaneous injection of 10(7) cells in foot of hind leg of (CBA X C57BL/6)F1 hybrids. The enhancement of(More)
Triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) serum content was measured in mice during systemic "graft-versus-host" reaction (GVHR), using radioimmunoassay. It was demonstrated that on the 3rd day after GVHR induction the levels of these hormones did not differ from the control values. T3 and T4 concentrations and 125I(More)
An important role in the pathogenesis and outcome of burn trauma is played by infectious complications, due to a disturbance of the immunologic reactivity of the victim [12]. Thermal burns are powerful stress factors, and for that reason a special place among responses of the burned individual is occupied by adrenocortical function and the level of(More)
A new method of injecting parental lymphocytes into the foot of F1 hybrid mice to induce a local graft versus host reaction, based on the use of the Achilles' tendon as a natural “shutter” covering the lumen of the wound channel, is suggested. The new method of injection greatly simplifies the test and enables the conditions for its performance to be(More)
Development of the graft versus host reaction (GVHR) was studied in female (CBA×C57BL/6)F1 mice during pregnancy, and after birth or the day before mating with syngeneic, semisyngeneic, and allogeneic males. The development and outcome of the GVHR in the female mice was shown to depend on genetic differences between the donors of transplanted lymphocytes(More)