We have synthesized several derivative of dl-threo-methylphenidate (Ritalin) bearing substituents on the phenyl ring. IC50 values for binding these compounds to rat brain monoamine transporters were assessed using [3H]WIN 35,428 (striatal membranes, dopamine transporters, DAT), [3H]nisoxetine (frontal cortex membranes, norepinephrine transporters, NET) and… (More)
FUNDING: Overall, 2004-2005 was another excellent year in which the department continued to excel in education, research and service. Research funding in the department was $4,501,221 (total costs) in NIH support (source: NIH Website). This is a decline of about 2 million from the previous year. While this decline is large and concerning, a major… (More)
A survey of Cannabis users reveal that long-term use of the drug does not produce any harmful effect. The findings of this scientific study is reported here minutely.
Diabetes mellitus is a common problem in clinical practice. An indigenous herbal drug Arani (Clerodendron phlomidis) was selected for this experimental and clinical study. The experimental study was conducted on albino rats. Arani inhibited the adrenaline induced hyperglycaemia effectively. The alcoholic extractive of Arani produced a well comparable fall… (More)
The efficacy of Vasa (Adhatoda vasica) in the form of syrup against Non-ulcer Dyspepsia (Amiapitta) through a clinical trial is attempted here. This trial showed hopeful results. The drug has reduced the total and free HCL in the patients of hyperacidity and hyperchlorhydria.