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Transit times of individual polymorphonuclear leukocytes (PMN) through cylindrical micropores with a diameter of 8 microns and a length of 19 microns were measured at pressure gradients of 3 to 10 cm H2O using the Cell Transit Analyzer (CTA); this system employs a conductometric principle and provides a frequency histogram of transit times for greater than(More)
OBJECTIVE To investigate single neutrophil flow resistance in coronary artery disease, including myocardial infarction before initiation of reperfusion therapy. DESIGN Neutrophil flow resistance was measured in 93 subjects in five groups: (group 1) 28 patients within 12 hours after the onset of myocardial infarction, before reperfusion therapy; (group 2)(More)
There is an increasing interest in the role of coagulation factor XIII (FXIII) in cardio- and cerebrovascular diseases. It has recently been reported that a common G-->T point mutation in the A-subunit gene of FXIII, which codes for a valine (val) to leucine (leu) change (FXIIIVal34Leu), is protective against thrombotic diseases but seems to increase the(More)
OBJECTIVES This study sought to investigate hemostatic predictors of subacute occlusive coronary stent thrombosis. BACKGROUND Better hemostatic monitoring may improve antithrombotic therapy after stenting. METHODS In 140 consecutive patients undergoing Palmaz-Schatz stent implantation for suboptimal angioplasty results, we obtained serial blood samples(More)
The objective of the study was to identify the relative importance of erythrocyte flow resistance and aggregation in acute and chronic coronary syndromes. 117 subjects in five groups were studied: (1) 34 patients shortly after acute myocardial infarction (AMI) before reperfusion therapy; (2) 27 patients with unstable and (3) 21 with stable angina pectoris(More)
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