G. Marshall

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There is growing evidence that corrective input for grammatical errors is widely available to children (Farrar, 1992; Morgan, Bonamo & Travis, 1995). However, controversy still exists concerning the extent to which children can identify and exploit available negative input. In particular, very little is yet known about the longer-term effects of negative(More)
Light activated rhodopsin interacts with domains on all three subunits of transducin. Two of these domains, the C-terminal regions of the alpha and gamma subunits mimic the ability of transducin to stabilize the active conformation of rhodopsin, metarhodopsin II, but display different roles in transducin activation process. Whether the interactions are with(More)
A preliminary multiobjective analysis of the chemotherapeutic benefits of hairpin-linked polyamides
Introduction Light-induced activation of rhodopsin (R*) leads to its conformation change and the binding of transducin G t. Synthetic G t α (340-350) peptide has been demonstrated to stabilize R* as does G t. The bound conformation of R*-bound G t α (340-350) has been determined by TrNOE NMR measurements [1]. The adjacent disposition of the ε-amino group of(More)
Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on the commercial source. Here we identify a minor contaminant (pepstatin butyl ester) as the active anti-parasitic principle. We synthesize a series(More)
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