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Ultrastructural changes in endothelial cells (EC) of myocardial capillaries were studied in 24 dogs which underwent hypothermia without perfusion. Biopsy specimens for electron microscopy were taken from the left ventricle of each dog in the control group, during anesthesia (prior to active cooling), and at the end of moderate (28-30 degrees ) and deep(More)
Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic damage to vascular and perivascular(More)
Similarity of the structural characteristics of perfusion capacity of right-atrial and leftventricular capillaries of the dog heart in health were detected, the capillaries differing significantly by size and by the majority of the morphometrical values. Exposure of animals to hypothermia induces different ultrastructural responses of the capillaries in two(More)
Surgical correction of complicated congenital heart disease in infants is terminated by postischemic reperfusion of myocardium accompanied with closure of more than 20% microvessels in the coronary bed by edematous endothelial cells, their bleb-like fragments, and aggregates of the blood formed elements. Degradation of the transmission capacity of the(More)
Cardiosurgical stress initiates endothelial injury of the colliquation necrosis type (without activating coagulation necrosis) in coronary capillaries of infants aged under 1 year. The dark cells exhibited high tolerance to operation stress in the presence of labile ultrastructural response of endothelial cells of the main and light types. The percentage of(More)
In patients with chronic myocardial tissue hypoxia irrespective of the disease (Fallot's tetralogy, coronary disease) factors of cardiosurgical stress initiate a drop of secretory production in coronary capillary endothelium and obstruction of the intravascular space by blood cells. In children the peak of exocytosis of secretory granules coincides with the(More)
It has been found that, in children with Roger’s disease corrected under conditions of two fundamentally different procedures of anesthetic management, myocardial reperfusion after cardiac arrest under artificial hypothermic circulation is accompanied with obstruction of more than 70% of coronary bed microvessels, one-third of them being blocked with(More)
on the number of microspheres immobilized in the left ventricular myocardium is shown in Fig. 3. A significant decrease of the cardiac index was observed only after about 150,000 micro s spheres/g had entered LV. In this series of investigations strong correlation was not found between the decrease in basic contractility of LV and the number of microspheres(More)
In modeled aorta coarctation long-term functioning of collateral arteries is shown to be accompanied by activation of subintimal smooth muscle cells and elastofibrosis of the intima, which are a manifestation of hemodynamic arteriosclerosis.