G M Artykbaeva

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It is widely accepted that type II iodothyronine deiodinase (D2) is mostly present in the brain, where it maintains the homeostasis of thyroid hormone (TH) levels. Although intensive studies have been performed on activity and mRNA levels of the deiodinases, very little is known about their expression at the protein level due to the lack of specific(More)
Experiments were made on 100 random bred rats of various age groups, controls and animals exposed to single external gamma-radiation at a dose of 1 Gy on the 35th day of life. Thyroxine and triiodothyronine concentrations were investigated in peripheral blood and separately in arterial blood, in thyroid, portal and hepatic venous blood. The activity of T4(More)
The injection of 0.5 mM of adrenalin and 3.3 X 10(-3) M of propranolol in the thyroid artery of the thyroid lobe perfused in a thermostatic chamber (37 degrees C) 1h after the beginning of perfusion caused a decrease in the index of thyroid deiodination by 48 and 37%, respectively. Adrenalin injection 2 h after TSH lowered the stimulating effect of the(More)
Rat liver and kidney microsomal fractions contain 5'-deiodinase, converting thyroxin into 3,5,3'-triiodothyronine. In control animals a marked decrease in thyroxin concentration takes place when the blood passes through the liver and kidney (triiodothyronine level being preserved). Fasting causes a prominent decrease in blood thyroxin, a small decrease in(More)
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