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1. We have developed a 16-compartment model that reproduces most of the features of the CA1 pyramidal cell electrophysiology observed experimentally. The model was constructed using seven active ionic conductances: gNa, gCa, gDR, gCT, gA, gM, and gAHP whose kinetics have been, inferred, in most cases, from the available voltage-clamp data obtained from(More)
A model of the hippocampal granule cells was created that closely approximated most of the measured intracellular responses from a neuron under a variety of stimulus conditions. This model suggests that: (1) A simple, four-conductance model can account for most of the intracellular behavior of these neurons. (2) The repolarization mechanism in granule cells(More)
Phase-plane analysis of the ionic currents underlying dendritic plateau potentials was carried out to study the nonlinear dynamics and steady-state transfer properties of the dendritic tree in cerebellar Purkinje cells. The results of an analysis of the P-type calcium and delayed rectifier potassium channel system are presented in this study. These channels(More)
BACKGROUND Little is known about the actual treatment of patients with chronic obstructive pulmonary disease (COPD), either in the inpatient or outpatient settings. We hypothesized that there are substantial opportunities for improvement in adherence with current guidelines and recommendations. METHODS We reviewed the medical records of all patients(More)
RATIONALE Efforts to reduce 30-day readmission have mostly concentrated on addressing deficiencies in care transitions and outpatient management after discharge. There is growing evidence to suggest that physical inactivity is associated with increased hospitalizations. OBJECTIVES We examined whether or not a potentially modifiable factor such as regular(More)
The effects of low dose ethanol treatment on neuronal firing threshold were studied in dentate granule neurons using intracellular recording. A higher threshold for orthodromic activation and lower threshold for somatic activation were observed in 50 mM of ethanol, based on an examination of the excitatory postsynaptic potentials, strength duration and(More)
Using the indirect antibody peroxidase-antiperoxidase method of Sternberger, we localized substance P (SP), somatostatin (SOM), enkephalin (ENK), and serotonin (5HT, 5-hydroxytryptamine) in the spinal cord of Rana pipiens. This is the first study to demonstrate all four substances in adjacent sections of frog spinal cord. The distribution patterns of ENK,(More)
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