G. K. Zairov

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DNA intercalation by small chemical molecules can result in frameshift mutagenesis and chromosomal breakage. With evidence mounting that broadly diverse structures are capable of intercalating between DNA base pairs, it becomes important to better define those structural features that enhance intercalation strength and those that confer genotoxicity(More)
The paper deals with observations of the patients with non-A-non-B hepatitis (NANBH) transmitted by the fecal-oral mode. The disease was diagnosed by ruling out other similar diseases of the liver, primarily viral A (HA) and B (HB) hepatitides, using clinical and epidemiological data and highly sensitive methods of laboratory diagnosis of HA and HB. Cases(More)
Virologic, serologic, biochemical, and morphological data characterizing spontaneous hepatitis A (HA) in cynomolgus macaques (Macaca fascicularis) and green monkeys (Cercopithecus aethiops) are reported. Experimental HA was induced in macaques as a result of infection with human hepatitis A virus (HAV-h). Disease similar to human HA was induced in(More)
Fecal specimens collected in the early stage of the disease from hepatitis patients classified by serological, clinical, and epidemiological data as non-A-non-B hepatitis were examined by means of cross immune electron microscopy. Extracts of feces from such patients were found to contain full, semi-empty, and empty virus particles without envelopes, 27-30(More)
An increase in the incidence of viral hepatitis was observed in the autumn of 1986 in one of the districts of southern Uzbekistan. The clinico-epidemiological data and highly sensitive tests for hepatitis A (HA) and B (HB) markers showed the absence of HB infection in most of the patients and prevalence of HA among children. In 68.7% of the patients,(More)
The urgency of obtaining an adequate and accessible experimental model of human hepatitis A (HA) is determined by its importance for health and a universal increase in the prevalence of this disease in recent years. At present as a model of HA we use chimpanzees (Pan troglodites) [11], marmosets (Saquinas mystax) [10], and nocturnal monkeys (Aotus(More)
Hepatitis A infection characterized by virus excretion in feces, synthesis of specific IgM antibody, increased activity of alanine aminotransferase in the blood serum, and a complex of morphological lesions in the liver typical of acute hepatitis was reproduced in M. fascicularis (M. f.) and Macaca rhesus (M. r.) using 2 strains of hepatitis A virus (HAV)(More)
The method of molecular hybridization of nucleic acids of oncornavirus type D produced by HEp2 cells with cellular nucleic acids was applied. No sequences homologous to the viral nucleic acids were found in normal human embryo cells as well as in bovine, porcine, murine, and chicken cells. No such sequences were found in tissues of malignant lymphomas.(More)