G K Rajanikant

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BACKGROUND AND PURPOSE Carnosine is a naturally occurring dipeptide with multiple neuroprotective properties. In addition, it is well tolerated in high doses with minimal side effects. The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of(More)
Statins are currently among the most commonly prescribed agents for the prevention of cardiovascular disease. Statins reduce serum cholesterol levels by reversibly inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis, in the nanomolar range. Mounting evidence suggests that in addition to their(More)
Carnosine is a naturally occurring pleotropic dipeptide which influences multiple deleterious mechanisms that are activated during stroke. Numerous published studies have reported that carnosine has robust efficacy in ischemic stroke models. To further evaluate these data, we have conducted a systematic review and meta-analysis of published studies. We(More)
Ischemic stroke is the second leading cause of death and long-term disability worldwide, for which no effective therapies are available. The increasing prevalence of ischemic stroke and related health risks, combined with the lack of effective therapies, highlight the desperate need for continued research for exploring the safe and effective drugs, which(More)
There is no doubt that ischemic stroke prevention, management and treatment necessitate a better understanding of its pathophysiology. Part 1 of this theme issue described the role of thrombomodulin, calcium and inflammation in ischemic stroke, and covered topics related to mechanisms of neurovascular dysfunction and synaptic and extrasynaptic glutamate(More)
Acute ischemic stroke is the most common cerebrovascular disease and a leading cause of long-term disability, mortality and human suffering. The most common cause of ischemic stroke is sudden occlusion of a blood vessel, eventually leading to the death of neuronal, glial, and endothelial cells. Current knowledge regarding the pathophysiology of cerebral(More)
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