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Journals and Conferences
It has been found that the effect of whole-body gamma-irradiation with doses of 10 and 150 Gy on the haemodynamics regulation varies. Thus, the dose of 10 Gy does not change the arterial tension and the dose of 150 Gy decreases the arterial tension 6 and 24 hr after irradiation, the nociceptive reactions of haemodynamics being invariable with both doses.
With radiation injury caused by superlethal doses of 150 Gy the analgesic effect of narcotic drugs decreases and the level of drug analgesia depends on the initial status of nociceptive reactions. The role of mu-opiate mechanisms in the development of postirradiation analgesia to thermal stimuli has been determined.
It was shown that during 24 h following whole-body exposure of male rats to gamma-quanta (150 Gy) the latent period of their response to the thermal effect increased a "tail-flick" test) and the threshold of the nociceptive response to an electric stimulus (the vocalization threshold) decreased. A correlation was found between the initial response to the… (More)