G. J. Mannering

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3-O-[1'-14C]Ethylmorphine and ethylmorphine, respectively, were used to measure O- and N-dealkylase activities of hepatic microsomes. The well-known sex difference in the rate of N-delakylation in mature rats was not observed with O-dealkylation, nor did O-dealkylase activity increase as male rats reached maturity, as is the case with N-dealkylase activity.(More)
1. Colupulone, a constituent of hops, was shown to be a potent inducer of hepatic P4503A in mouse. The olefin, 2-methyl-3-buten-2-ol (RC = CH2), is formed from lupulones when hops are exposed to atmospheric hydroxyl radicals. This suggested the possibility that the same reaction may occur in vivo. The credibility of this hypothesis was enhanced when RC =(More)
The following pathway for benzphetamine (Bz) metabolism in rat hepatic microsomes was established: Bz leads to norbenzphetamine (NorBz) leads to N-hydroxynorbenzphetamine leads to N-benzylethyl-alpha-phenylnitrone leads to 2-nitroso-1-phenylpropane. The last product forms a complex with cytochrome P-450 with an absorbance maximum at 455 nm. Steps 1, 2, and(More)
Previous to 1950, when Bonnichsenl isolated crystalline alcohol dehydrogenase (ADH) and showed that it did not react with methanol,$ it was believed that the ADH system was responsible for the oxidation of all primary aliphatic alcohols, including methanol (FIGURE 1 ) . This observation redirected attention to the peroxidative system as a means of oxidizing(More)
Immediately after recovery from hexobarbital anesthesia, mice were injected intraperitoneally with one of the following interferons: natural mouse alpha/beta, recombinant mouse (rmouse gamma IFN-A) or human alpha A, alpha D, alpha AD interferon (rHu alpha IFN-A, rHu alpha IFN-D, rHu alpha IFN-AD). All of these interferons, except rHu alpha IFN-A induced(More)
1. Components of the hepatic monooxygenase systems (cytochrome P-450, cytochrome b5, NADPH cytochrome P-450- or c-reductase) of the brown trout (Salmo trutta), leopard frog (Rana pipiens) and garter snake (Thamnophis) were considerably lower than those found in the rat. 2. Reactivity of snake NADPH-cytochrome P-450-reductase with cytochrome P-450 was about(More)