G Iu Grigorian

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The properties of beta-adrenoreceptors (beta-AR) have been studied in endothelial cells from the human pulmonary artery (EPA) and umbilical vein (EUV). [125I] Iodosyanopindolol binding assay revealed the amount of 22 and 12 fmol/10(6) cells as well as Kd = 92 and 52 pM for EPA and EUV, respectively. Adrenergic agonists increased the cAMP levels in EPA in(More)
In conditions of acute experiment on white rats anaesthetized by Nembutal (40 mg/kg, intraperitoneally), the registration and analysis of background impulse activity of the supraoptic nucleus neurons of rats' hypothalamus in norm and after electromagnetic irradiation of millimeter wavelength on organism, were carried out. Distributions of neurons by the(More)
By studying the effects of oxygen deficiency upon signal-transducing system it has been shown that in long hypobaric hypoxia activates PI-turnover in cultured human endothelial cells. The sensitivity of cells to histamine was decreased as well as the adenylate cyclase activity in membranes of this cells. The amount of beta-adrenoreceptors was not influenced(More)
The modified method for the isolation and purification of B. pertussis toxin has been proposed. Chromatography with the use of hydroxylapatite and lentil lectin--Sepharose 4B has permitted the isolation of the preparation purified 600 times. Its molecular weight is about 90,000. The preparation has been found to possess leukocytosis-stimulating,(More)
Solubilization of adenylate cyclase by lubrol PX results in a loss of the enzyme sensitivity to hormones; however, the enzyme retains its ability to be activated by guanyl nucleotides and NaF. Lubrol WX devoids adenylate cyclase of its sensitivity to hormones and NaF. Solubilization causes a shift in the pH optimum of the enzyme towards neutral values of pH(More)
Antigen-IgE-antibody interaction on the cell surface in an allergic reaction increases methylation of phospholipids of a cell membrane making it permeable for Ca2+ ions. Therefore of interest is a study of free intracellular Ca2+ concentration from a view-point of development of atopic bronchial asthma and the use of extracorporal methods of its therapy(More)
The effect of cardio- and neurotropic drugs was studied on beta 2-adrenergic receptors and coupled adenylate cyclase (AC) from rat reticulocytes. Trifluperazine, chlorpromazine, levomepromazine, metaphenazine, haloperidol, (+) and (-) isomers of butaclamol, as well as imipramine, vinblastine and verapamil, at a concentration of 10(-4) M failed to influence(More)
Epinephrine (E) and norepinephrine (NE) alone did not increase free intracellular Ca2+ ([Ca2+]i) in human platelets loaded with Quin-2 or Fura-2; however, they did potentiate the effects of vasopressin (VP), serotonin (S) and platelet activating factor (PAF). The synergism in [Ca2+]i increase was also obtained in the presence of VP together with PAF, S with(More)