G. I. Storozhakov

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BACKGROUND Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. METHODS AND RESULTS In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial(More)
BACKGROUND Bronchial asthma is a chronic respiratory disorder characterized by airway inflammation, airway hyperresponsiveness, and periodic reversible airway obstruction. Subtype 2 helperT cell (T(H)2) cytokines play an important role in the development of allergic airway inflammation in patients with bronchial asthma. OBJECTIVE To investigate whether(More)
In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC in CARD15 gene and Asp299Gly in TLR4 gene contribute to atopic bronchial asthma we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian patients from Moscow. DNA samples from 283 patients with atopic bronchial asthma and(More)
Acute experiments on cats show that DAGO, a selective μ-opiate receptor agonist, elicits a pronounced antiarrhythmic effect in ischemia-induced arrhythmias. The protective effect of DAGO is observed only under conditions of intact parasympathetic innervation of the heart and apparently depends on then. vagus activity and stimulating effect of DAGO on(More)
weeks postoperation, 22-26% thymus involution was observed in the animals with marked autotomy. Adrenal hypertrophy was found 2-6 weeks postoperation in the rats with severe autotomy, 7-8 weeks postoperation in the rats with severe and mild autotomies, and in the animals with repeated autotomies. Thus, the model of DPS caused by transection of the sciatic(More)
In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A1–13 on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor(More)
Preliminary administration of dynorphin A1–13 to narcotized cats with myocardial ischemia attenuated cardiac fibrillation, but increased the incidence of ventricular tachycardia. Protective effect of dynorphin A1–13 was observed only under conditions of intact sympathetic cardiac innervation.
The effects of the opiate receptor agonists dalargin and β-endorphin on the occurrence of idioventricular arrhythmias, including ventricular tachycardia and fibrillation, are studied in acute experiments on Nembutal-anesthetized cats. Dalargin administered in the dose crossing the blood-brain barrier produces a pronounced antiarrhythmic effect, while(More)
The role of the autonomic nervous system in the development of ischemic cardiac arrhythmias was studied in acute experiments on cats receiving thyrotropin-releasing hormone. Bilateral vagotomy attenuated, while bilateral transection of cardiac branches of the stellate ganglia completely abolished the antiarrhythmic effect of thyrotropin-releasing hormone.