G. I. Poletaev

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The changes of the muscle fibres volume and resting membrane potential (RMP) were studied following treatment with hypertonic medium and furosemide. The volume changes in hypertonic medium began with cell shrinkage and later have been followed by the volume increase up to normal level during 30-40 minutes. At the same time the medium hypertonicity caused(More)
A decrease in resting MP, increase in the input resistance, appearance of anode breakdown APs, and extrajunctional acetylcholine sensitivity following denervation were revealed in the rat diaphragm muscle fibres. Addition of 1 X 10(-4) M furosemide to the culture medium reduced the degree of post-denervation muscle membrane depolarization and of(More)
The volume change of the muscle fibres in the hypertonic medium begins with cell shrinkage. Later the cell volume increases up to the normal level because of the furosemide-sensitive CL(-)-influx activation. The property of the Cl(-)-influx to be activated in the hypertonic medium is abolished after denervation. That causes a loss of the ability of muscle(More)
The effect of norepinephrine, histamine, serotonin and potassium chloride on electrogenesis and contraction was studied on innervated and denervated smooth muscles of cat's nictitating membrane. Denervated smooth muscles generate slow depolarizing potentials with the APs corresponding to tonic and phasic contractions, resp. Tonic contractions occur with no(More)
Blocking of myoneural transmission resulting from indirect low-frequency stimulation (fatigue) was not followed by amplitude changes in miniature end-plate potentials and acetylcholine-potentials. A conclusion was drawn that in performed experiments the acetylcholine sensitivity of the postsynaptic membrane was not changed and the decrease of endplate(More)
Electric properties and acetylcholine sensitivity in frog sartorius muscle fibres were investigated after denervation and after prolonged paralysis with d-tubocurarine and alpha-bungarotoxin. No changes similar to those that appeared after nerve section developed in the muscle fibres after d-tubocurarine or alpha-bungarotoxin treatment. It is suggested that(More)
Evoked and spontaneous end-plate currents (EPC) were studied in normal voltage-clamped frog sartorius muscle fibers and 2 weeks after application of colchicine to the nerve innervating the muscle to block axoplasmic transport in its fibers. Application of colchicine was found to reduce the rate of rise and to prolong decay of EPC without affecting the(More)
Experiments were performed on the nerve trunks of frogs in which the production of acetylcholine was disturbed by removal of the pancreas. This brought about an increase of the negative afterpotential and prologation of tetanized single response on the 4th to 10th day following the operation. The compensatory administration of acetylcholine removed these(More)