G H Cardinet

Learn More
A polysaccharide storage myopathy is described in nine Quarterhorses, Quarterhorse crossbreds, American Paints and Appaloosa horses which had a history of recurrent exertional rhabdomyolysis. Muscle biopsies were characterized by high muscle glycogen concentrations with up to 5% of type 2 muscle fibers containing inclusions which stained positively with the(More)
The myofiber type composition was studied in 42 different muscles of the dog to determine if there are unique features that might explain the preferential involvement of the muscles of mastication by inflammatory myopathies. The principal myofiber types for most muscles studied were type 1 and type 2A and, to a lesser extent, type 2C, whereas the dorsal(More)
Two 5-month-old male Domestic Shorthair littermates showed general skeletal muscle hypertrophy, multifocal submucosal lingual calcification with lingual enlargement, and excessive salivation. Both cats had a reduced level of activity, walked with a stiff gait, and tended to "bunny hop" when they ran. These clinical features were similar to those of(More)
Genetic defects of myophosphorylase in humans cause a metabolic myopathy (McArdle's disease) characterized by exercise intolerance, cramps, and recurrent myoglobinuria. Recently, a breed of cattle with myophosphorylase deficiency has been identified: this is the first animal model of McArdle's disease. To define the molecular genetic error in the cattle, we(More)
Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. In human MG patients and in animals(More)
The effects of serotonin on the contractile properties of the soleus and extensor digitorum longus muscles in mice were studied after chronic intraperitoneal administration with and without a recovery period, and compared to contractile studies of the same muscles performed after acute administration of serotonin. A curarized in vitro preparation of both(More)
The total number of myofibers contained in the transverse sections of 6 canine pectineus muscles was counted, using direct- and indirect-counting methods. For the direct-counting method, the transverse section of each muscle was photographed, from which a montage of each section was constructed. Then, the total number of myofibers contained in each montage(More)
  • 1