G. Giannopoulos

Learn More
The metabolism of cortisone (E) and cortisol (F) by human placenta, decidua, myometrium, chorion and amnion during pregnancy was studied in vitro. Early pregnancy, midpregnancy and term placentae metabolized F efficiently yielding E as the major product. The capacity of the placenta to inactivate F to E was observed as early as the 8th week of pregnancy and(More)
Exchange assays have been developed and used to measure the total concentration of estrogen receptor sites (unoccupied and occupied with endogenous hormone) in the cytosol and nuclei of human myometrium during the menstrual cycle and in pregnancy at term, before and during labor. A major fraction of the nuclear receptors appear to be unoccupied (not(More)
High affinity (KD = 0.2 nM), low capacity (3.6-5.0 fmol/mg protein), androgen-specific binding proteins with characteristics typical of androgen receptors were identified in the lungs of rabbit fetuses between the 26 and 29th day of gestation and in the lungs of adult rabbits. While androgen receptor concentrations increased significantly from late(More)
The binding of [3H]dexamethasone to cytosol fractions of human myometrium, endometrium, decidua, chorion, amnion and placenta has been studied. All tissues examined contained high affinity, low capacity binding sites with high specificity for glucocorticoids. Maximum specific binding of [3H]dexamethasone was reached after about 10 h at 0-4 degrees C and(More)
The steroid-binding affinities and specificities of pulmonary glucocorticoid receptors have been examined in different mammalian species. The receptors of all species examined are highly specific for binding glucocorticoids, the order of binding affinity being similar to the order of their biological potency. Progesterone also binds significantly to the(More)