G. G. Isaev

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The development of fatigue was investigated in the diaphragm of anaesthetized, tracheostomized, spontaneously breathing cats during restricted air flow. Ventilation, transdiaphragmatic pressure (Pdi), integrated electrical activity of diaphragm (Edi) and phrenic nerve (Eph) were measured simultaneously and expressed as a percentage of values at unloaded(More)
A study involving nine healthy males was conducted to determine the developmental rate of inspiratory muscle fatigue during resistive loads under normoxic and hypoxic conditions. The subjects aged 19 to 38 years performed a bicycle exercise test of increasing power during an exhaustive inspiratory–expiratory resistive load of 40 cm water column/l s–1(More)
The purpose of the present study has been to determine whether pharyngeal dilator muscles participate in inspiratory load compensatory responses and if so, to elucidate role of upper airway mechanoreceptors in these responses. The experiments were performed on anaesthetized rabbits. Each animal was tested in three ways by the imposition of inspiratory(More)
The review is dedicated of phenomenology of the difficult breathing and analysis of the peripheral and central mechanisms of it. Analysis based on model investigations with resistive loads in awake or sleeping healthy humans, including results of experiments in the anesthetized animals. The recent data having principle importance in estimation of the(More)
In 18 anesthetized cats, electrical activity of diaphragmatic nerve, external intercostal muscles and diaphragm, was monitored. Starting from a certain level of inspiratory load, the transdiaphragmatic pressure and the diaphragm EMG decreased, the efferent activity of diaphragmatic nerve remaining the same. This data suggests a peripheral character of(More)
In anesthetised spontaneously breathing rabbits, an increase in the inspiratoryactivity m.genioglossus was greater than a simultaneous increase in the respiratory activity of the diaphragm cluring loaded breathing. A bypass of the air flow via tracheostoma did not affect the response of the m.genioglossus to a resistive load. The difference seems to be due(More)
The present study was undertaken to test the hypothesis that recruitment of upper airway muscles in loaded breathing is a result of integration of peripheral chemoreceptor and pulmonary mechanoreceptor afferents. Experiments were performed in spontaneously breathing tracheostomized anesthetized rabbits. It had been studied the effects of inspiratory(More)