G. G. Barsegyan

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Psychoemotional stresses may lead to the onset and development of ulcers in the gastrointestinal tract, neuropsychopathies, and cardiovascular and other diseases [6, 7, 10, 11]. In addition, there is experimental and clinical evidence of individual reactivity to the action of stressors. In particular, not all persons or animals in the same stress-inducing(More)
Inclusion of L-DOPA, the standard Parkinson’s disease medication, into polymeric particles (PLGA) results in optimization the drug metabolism and increasing its bioavailability, significantly increases of physical endurance, better coordination and lower anxiety in Wistar rats, when chronically administered nasally.
Mental stress is the cause of a number of pathological states, including cardiac arrhythmia. Changes in the electrical stability of the heart are considered to play an important role in the genesis of stress-induced heart damage. Taking into account the peculiar importance of membrane disorders in the changes of the automatism, excitability, and(More)
Stress at different stages of pregnancy in rats, and also in the period immediately before mating, causes an increase in postnatal mortality and the appearance of a physiologically immature progeny with smaller body weight, delayed ossification, delayed eye opening, and defective orientation, which as has been suggested [i, 8, ii, 14], are associated with(More)
Research into the concrete neurochemical mechanisms of the brain during realization of behavioral reactions in various extremal situations has drawn attention to the important role of the dopaminergic systems of the brain in these processes It has been suggested that an important role in the choice of an adequate strategy is played by dopaminergic systems(More)
The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced(More)
Individual sensitivity of organisms to drugs modifying the functional properties of systems controlling the level of emotional reactivity is an extremely urgent problem. The action of anxiety-inducing agents on learning has been inadequately studied [2], and individual differences in this matter remain virtually unstudied. Accordingly the comparative study(More)
We studied immediate and delayed effects of intraventricular injection of 1,2-epoxypropyltrimethylammonium chloride on behavioral reactions in rats. Apomorphine-induced yawning increased and orientation and exploratory activity was improved 144 h postinjection, which indicates activation of the brain dopaminergic system during this period.
i. S. G. Blagorodov and A. P. Shepelev, Khim. Farm. Zh., No. 3, 293 (1987). 2. V. M. Vinogradov, L. V. Pastushenkov, and E. N. Sumina, Patol. Fiziol., No. 4, 81 (1981). 3. V. B. Grechin and V. N. Borovikova, Slow Noneleetrical Processes in Assessment of the Functional State of the H,,man Brain [in Russian], Leningrad(1982). 4. E. V. Gubler and A. A. Genkin,(More)
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